Albiflorin alleviates cognitive dysfunction in STZ-induced rats

Song, Min Seob; Yan, Yong; Ren, Gaofei; Hou, Jingwen; Qin, Guijun; Wang, Wang; Li, Zhizhen

doi:10.18632/aging.203274

Cited by 25 publications

(21 citation statements)

References 24 publications

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“…Recent studies have proved that traditional Chinese medicine was efficient in relieving inflammatory response and GDM. For instance, puerarin treatment improved the expression of IRS-1, TLR4, MyD88, and NF-κB in GDM rats (Ma et al, 2021). Resveratrol treatment brought about improved maternal glucose and lipid homeostasis in both C57BL/KsJ-Lep (db/+) mouse and streptozotocin-induced diabetes animal model.…”

Section: Discussionmentioning

confidence: 96%

The effects of Oldenlandia diffusa water extract on glucose metabolism and inflammation level in rats with streptozotocin-induced gestational diabetes mellitus

Xie

Wang

Cao

et al. 2022

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To reveal the effects of Oldenlandia diffusa (OD) on relieving the progression and development of gestational diabetes mellitus (GDM), and explore the underlying mechanism. A rat model of GDM was established by streptozotocin injection. The effects of OD on GDM rats were evaluated by measuring the levels of fasting blood glucose (FBG), insulin, and hemoglobin A1c (HbA1c), and exposing to oral glucose tolerance test (OGTT) and histological evaluation of the pancreas. The levels of insulin and inflammation response-related factors (tumor necrosis factor [TNF]-α, Interleukin [IL]-6 and IL-1β) were evaluated by enzyme-linked immunosorbent assay (ELISA). Additionally, immunoblot assay was performed to investigate the effects of OD on the nuclear factor-κb (NF-κB) pathway and 5' adenosine monophosphate-activated protein kinase (AMPK) pathway. OD decreased blood glucose level, pancreatic tissue damage, and insulin secretion in GDM rats. OD also reduced serum inflammatory levels (TNF-α, IL-6, and IL-1β) in GDM rats. Mechanically, OD could inhibit NF-κB pathway and activate AMPK pathway in the pancreatic tissue of GDM rats. OD affected glucose metabolism and inflammation level in rats with streptozotocin-induced GDM, and the underlying mechanism was through AMPK pathway. OD might serve as a promising and potential drug for the treatment of GDM.

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Section: Discussionmentioning

confidence: 96%

The effects of Oldenlandia diffusa water extract on glucose metabolism and inflammation level in rats with streptozotocin-induced gestational diabetes mellitus

Xie

Wang

Cao

et al. 2022

qas

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“…The reduced levels of ROS and MDA in the hippocampus were often reported as the consequent events. Interestingly, many studies also mentioned the inhibited NF-κB signaling in addition to the Nrf2-mediated antioxidant response [7,106,114]. The upregulated expression of HO-1 protein in response to the Nrf2 upregulation suppresses the NF-κB activation which governs the transcriptions and productions of proinflammatory cytokines.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Mounting epidemiological studies showed that the risk of cognitive decline in middle-aged diabetic patients was 2-3 times higher compared with healthy peers [5,6]. Moreover, the prevalence of cognitive impairment is predicted to increase dramatically in the future with a longer survival time for diabetic patients [7]. Cognitive decline among children with T1DM is mainly manifested as subtle changes in cognitive development, whereas adults present subtle decrements in cognitive performance compared to age-matched controls [8].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Diabetes Mellitus and Its Management by Transcription Factor Nrf2-Mediated Antioxidant Defense System

Zhou¹,

Münch²,

Chang³

2023

Importance of Oxidative Stress and Antioxidant System in Health and Disease

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Diabetes mellitus has been an epidemic in the twenty-first century and an approximately 50% risk of diabetes predisposed to cognitive decline leading to dementia in humans. There is an urgent need to understand the pathophysiology and identify molecular targets of cognitive impairment in diabetes mellitus that might lead to improved therapy. Mounting evidence indicates that nuclear factor erythroid 2-related factor 2 (Nrf2) and its regulated downstream antioxidant genes are emerging therapeutic targets. In this chapter, we introduce cognitive dysfunction in diabetes mellitus and its hallmarks, particularly its pathological mechanisms related to oxidative stress in the brain, then justify the role of the transcription factor Nrf2-mediated antioxidant defense system in attenuating cognitive decline in diabetes mellitus. Studies on Nrf2 inducers sourced from natural products (i.e., sulforaphane, astaxanthin, resveratrol, quercetin) that have shown potent cognitive improvement in diabetic models are discussed. These studies have demonstrated that Nrf2 inducers drive the antioxidant and anti-inflammatory responses in the hippocampus region and effectively improve the spatial and memory function in diabetic rats/mice. However, evidence from large and well-designed clinical trials is warranted to support Nrf2 inducers as promising therapeutic agents in the management of cognitive impairment in diabetes mellitus.

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“…They can reduce neuroinflammatory reactions and regulate oxidative stress related reactions by regulating the autosecretory of nerve cells and the active factors secreted by glial cells. Albiflorin (AL) can reduce AD pathology and improve cognitive impairment by regulating oxidative stress and inflammation in the brain ( 18 ). Nobiletin(NOB) can regulate microglia and relieve neuroinflammation ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids are rich in many TCMs. They can reduce (18). Nobiletin(NOB) can regulate microglia and relieve neuroinflammation (19).…”

mentioning

confidence: 99%

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

et al. 2022

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The incidence of sporadic Alzheimer’s disease (AD) is increasing in recent years. Studies have shown that in addition to some genetic abnormalities, the majority of AD patients has a history of long-term exposure to risk factors. Neuroendocrine related risk factors have been proved to be strongly associated with AD. Long-term hormone disorder can have a direct detrimental effect on the brain by producing an AD-like pathology and result in cognitive decline by impairing neuronal metabolism, plasticity and survival. Traditional Chinese Medicine(TCM) may regulate the complex process of endocrine disorders, and improve metabolic abnormalities, as well as the resulting neuroinflammation and oxidative damage through a variety of pathways. TCM has unique therapeutic advantages in treating early intervention of AD-related neuroendocrine disorders and preventing cognitive decline. This paper reviewed the relationship between neuroendocrine and AD as well as the related TCM treatment and its mechanism. The advantages of TCM intervention on endocrine disorders and some pending problems was also discussed, and new insights for TCM treatment of dementia in the future was provided.

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Albiflorin alleviates cognitive dysfunction in STZ-induced rats

Cited by 25 publications

References 24 publications

The effects of Oldenlandia diffusa water extract on glucose metabolism and inflammation level in rats with streptozotocin-induced gestational diabetes mellitus

The effects of Oldenlandia diffusa water extract on glucose metabolism and inflammation level in rats with streptozotocin-induced gestational diabetes mellitus

Cognitive Impairment in Diabetes Mellitus and Its Management by Transcription Factor Nrf2-Mediated Antioxidant Defense System

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

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