ALBI and PALBI grade predict survival for HCC across treatment modalities and BCLC stages in the MELD Era

Liu, Po Hong; Hsu, Chia Yang; Hsia, Cheng Yuan; Lee, Yun Hsuan; Chiou, Yi You; Huang, Yi Hsiang; Lee, Fa Yauh; Lin, Han Chieh; Hou, Ming; Huo, Teh Ia

doi:10.1111/jgh.13608

Cited by 139 publications

(150 citation statements)

References 23 publications

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“…Additionally, albumin, as part of the ALBI grading system, has been shown to be a quantitative, useful and prognostic indicator of liver dysfunction in HCC patients (21)(22)(23)(24)(25). Albumin has previously been reported to have direct HCC growth inhibitory properties in vitro (26,27), and there is also suggestive clinical evidence for an inhibitory effect on HCC in patients (30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Carr

Guerra

2017

Int J Biol Markers

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ORIGINAL RESEARCH ARTICLEFurthermore, albumin values have been used in the 2-parameter albumin-bilirubin (ALBI) quantitative grading system for liver function in HCC, which has in turn been incorporated into several staging systems (21-25). There is thus much recent interest in serum albumin levels in prognostication, mainly as a reflection of liver function in HCC. However, there is also some direct experimental evidence that increased albumin levels can actually suppress HCC cell growth (26,27). Viewed this way, albumin levels may influence prognosis as much by their actions on HCC biology as by their reflection of impaired liver function.In this study, we examined the clinical correlations of serum albumin levels in a large HCC patient cohort with parameters of HCC behavior, and found an inverse relationship between serum albumin levels and HCC aggressiveness. Methods Patient dataWe retrospectively analyzed a prospectively collected database of 4,139 HCC patients, as previously reported (28,29), who had full baseline tumor parameter data, including computed axial tomography (CT) scan information on HCC size, number of tumor nodules and presence of PVT and plasma AFP levels; complete blood counts; routine blood liver function tests (total bilirubin, γ-glutamyl transpeptidase [GGT] and albumin); and patient demographics. Database management conformed to legislation on privacy, and this study conformed to the ethical guidelines of the Declaration of Helsinki. Approval for this retrospective study

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Section: Discussionmentioning

confidence: 99%

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Carr

Guerra

2017

Int J Biol Markers

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“…HCC was diagnosed by 4-phase multi-detector computed tomography (CT) scan, dynamic contrast-enhanced magnetic resonance imaging (MRI) [32,33]. Diagnosis of HCC was confirmed if there is one of the following three items: a) One or more of liver nodules > 1 cm in diameter in CT or MRI.…”

Section: Methodsmentioning

confidence: 99%

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

Mohammed¹

2017

GHOA

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Background: Vitamin D has emerging roles in fibrogenesis, cell cycle arrest, immune modulation, and tumorigenesis. Several single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are associated with tumorigenesis in various organs.Objective: to investigate the association between the VDR gene polymorphisms and Hepatocellular carcinoma (HCC) risk and severity in Egyptian patients with chronic hepatitis C (CHC). Methods:Five hundred thirty outpatients with chronic hepatitis C virus (HCV) infection were initially enrolled, of which 180 patients with CHC, 180 patients with liver cirrhosis and 170 patients with HCC. Another 170 age-and sex-matched healthy controls were enrolled. Genotyping of VDR gene at BsmI, ApaI and TaqI loci was performed. Evaluation of clinicopathological features of HCC was done. Data were analyzed using SPSS software (Version 17.0). Results Conclusion:The present study provided significant associations of VDR gene SNPs (ApaI CC genotype and bAt[CCA]-haplotype) with HCC development and disease severity in HCV-infected Egyptian patients. Thus, the determination of these VDR genetic variants in HCV patients could help identification of patients at-risk of HCC development.

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“…Liu et al [2] reported that the accuracy of PALBI grade was superior to that of ALBI. It is well known that the prognosis of a patient with HCC depends both on hepatic functional reserve and tumor factors.…”

Section: Tablementioning

confidence: 99%

ALBI Score as a Novel Tool in Staging and Treatment Planning for Hepatocellular Carcinoma: Advantage of ALBI Grade for Universal Assessment of Hepatic Function

et al. 2017

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ALBI and PALBI grade predict survival for HCC across treatment modalities and BCLC stages in the MELD Era

Abstract: Both ALBI and PALBI grade are adequate models to assess liver dysfunction in HCC. The PALBI grade is consistently better in all patients, in patients with minimally decreased liver function, and in patients receiving different aggressive therapies.

Cited by 139 publications

References 23 publications

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

ALBI Score as a Novel Tool in Staging and Treatment Planning for Hepatocellular Carcinoma: Advantage of ALBI Grade for Universal Assessment of Hepatic Function

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