Albendazole--objective evidence of response in human hydatid disease

Morris, David L.; Dykes, P. W.; Marriner, S. E.; Bogan, J. A.; Burrows, F. A.; Skeene-Smith, Hilary; Clarkson, M. J.

doi:10.1001/jama.253.14.2053

Cited by 121 publications

(55 citation statements)

References 15 publications

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“…( (4,14,21,22,27,31) regarding the findings of degenerative modifications in the cysts treated with benzoimidazole carbamates, relapses, and side effects. On the other hand, in our study, albendazole showed significantly more effective results than mebendazole in liver cysts, which differs from the findings of other authors (8).…”

Section: Discussionmentioning

confidence: 99%

Therapy of human hydatid disease with mebendazole and albendazole

Teggi

Lastilla

Rosa

1993

Antimicrob Agents Chemother

208

153

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We report our experience in the treatment with benzoimidazole carbamates (mebendazole and albendazole) of 337 patients affected by hydatid cysts with different localizations. The treated cysts showed degenerative modifications in 50.6% of the cases after mebendazole treatment and in about 80%o after albendazole treatment. Relapses after therapy were observed in 30%o of the cases; about 95% of the recurring cysts showed good susceptibility to a further cycle of therapy with benzoimidazole carbamates. Side effects observed with either drug were not severe and always reversible, consisting mainly of abdominal pains and increased levels of transaminases in serum. Among the factors that may influence the therapeutic results are the drug employed, the age of the cysts, the age of the patient, and the localization of the cysts and their morphological characteristics. Moreover, it can be hypothesized that each hydatid cyst has an intrinsic sensitivity to benzoimidazole carbamates.

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Section: Discussionmentioning

confidence: 99%

Therapy of human hydatid disease with mebendazole and albendazole

Teggi

Lastilla

Rosa

1993

Antimicrob Agents Chemother

208

153

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“…Albendazole is preferred when treating hydatid cysts of the liver, and successful results have been reported (Davis et al, 1986;Balik et al, 1999;Kurkcuoglu et al, 2002) reported partial or complete success rates as 14% in the mebendazole group and 30% in the albendazole group. There are studies reporting that medical treatment used pre-and post-operatively decreased the recurrence risk (Morris et al, 1985;Dhaliwal and Kalkat, 1997). Burgos et al (1999) recommend the use of albendazole preoperatively for 7-10 days and postoperatively one month in intact cysts and 3-6 months in ruptured cysts.…”

Section: Discussionmentioning

confidence: 99%

Treatment strategy for hydatid cysts with multiorgan involvement/localization

Şengül¹,

Büyükkarabacak²,

Yetim³

et al. 2013

jecm

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IntroductionHydatid cyst is a parasitic disease commonly observed in developing countries, where agriculture and animal breeding are widespread, and preventive medicine is not sufficient. Its incidence in Turkey is 2 in 100,000 people (Tatar et al., 2003).Hydatid cysts are caused by Echinococcus granulosus. Although the adult form of the parasite develops in the small intestine of main hosts carnivores such as dogs, wolves, and jackals. The larvae of the parasite settle in different organs of intermediate host herbivores such as cattle, sheep or goats, and humans and cause unilocular cystic Echinococcosis. When ingested by humans, the larval form of the parasite is broken down in the stomach, and the released embryo reaches the liver through the portal system. The disease is observed mostly in the liver (60%), which has a rich capillary network. Embryos that have passed the liver arrive in the right side of the heart via hepatic veins and the vena cava, ultimately reaching the pulmonary capillaries, where they embed themselves and cause the disease in the lungs (30%). Embryos that have entered the systemic circulation and cause the disease in other organs (10%) (Yüksel ve Kalaycı, 2001;Kılıç et al., 2010). Materials and methodsEighty patients treated and followed in our clinic for hydatid cyst between 2001 and 2011 were retrospectively studied. All of the patients were examined with chest X-Ray, computed tomography and ultrasonography. While the localizations of hydatid cysts of lung and liver were determined by using computed tomography (CT) and ultrasound (USG), for cardiac hydatid cysts, echocardiography and magnetic resonance imaging MRI were used. Twenty-four patients with multiorgan hydatid cysts were studied for the symptoms, localizations of cysts, complications and results of medical and surgical treatment. ResultsOf the patients, 12 were female and 12 were male. The mean age was 35 (13-76) years. The most common symptoms were

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“…10,13,15 In pregnancy, there is no place for chemotherapy with mebendazole or albendazole, as these can be embryotoxic, teratogenic and/or hepatotoxic. 8,[16][17][18] Some reports in the literature have suggested short-term small prophylactic doses of chemotherapy to prevent secondary deposits.…”

Section: Discussionmentioning

confidence: 99%