Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics

Dayan, Anthony D.

doi:10.1016/s0001-706x(03)00031-7

Cited by 316 publications

(291 citation statements)

References 29 publications

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“…This increase may result from the mode of action of PZQ that causes tegumentary damage among other effects, perhaps resulting in greater antigen exposition than that caused by benzimidazoles, which have a less aggressive mode of action (selective degeneration of parasite cytoplasmic microtubules, leading to decreased adenosine triphosphate formation and energy depletion). 36,37 However, this early increment in antigen OD levels was not predictive of antiparasitic efficacy.…”

Section: Discussionmentioning

confidence: 99%

Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model

González

Bustos

Garcı́a

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Taenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic pigs, which received different regimes of antiparasitic drugs (N = 39, 7 groups), prednisone (N = 5), or controls (N = 6). Samples were collected from baseline to week 10 after treatment, when pigs were euthanized and carefully dissected at necropsy. Antigen levels decreased proportionally to the efficacy of treatment and correlated with the remaining viable cysts at necropsy (Pearson's p = 0.67, P = 0.000). A decrease of 5 times in antigen levels (logarithmic scale) compared with baseline was found in 20/26 pigs free of cysts at necropsy, compared with 1/24 of those who had persisting viable cysts (odds ratio [OR] = 76.7, 95% confidence interval [CI] = 8

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Section: Discussionmentioning

confidence: 99%

Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model

González

Bustos

Garcı́a

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Some of them act through the generation of ROS and RNS in parasites (Docampo 1990, Dayan 2003. Studies carried out in recent years have indicated that these compounds may also cause oxidative stress in a host (Pinlaor et al 2008, Dewa et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Spodniewska¹,

Barski²,

Ziółkowski³

2014

Polish Journal of Veterinary Sciences

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The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD 50 for 5 consecutive days and pyrantel embonate (Group II) at a dose of 1/5 LD 50 for 3 consecutive days. The animals of group III were given both of the mentioned above compounds in the same manner as group I and II, but pyrantel embonate was applied on day 3, 4, and 5 from the beginning of dimethoate intoxication. Material from 6 rats randomly selected from each group was obtained after 3, 6 and 12 hours and 2, 7 and 14 days following the last applied dose of the compounds under study. It was found that application of pyrantel embonate caused only slight changes in the analysed parameters i.e. GSH, GPx and GR. Dimethoate administration caused disturbances in the antioxidative system manifested as a decrease in GSH concentration in the liver (max. -37.7% after 6 hours) and an increase of GPx and GR activities in erythrocytes (max. -21.7% and 29.6% after 3 hours, respectively), compared to the control group. The profile of changes after combined intoxication was similar, but their intensity was higher compared to the group of animals exposed to dimethoate only. Based on current studies, it was concluded that both dimethoate and pyrantel embonate at the applied doses showed a pro-oxidative activity.

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“…Among the benzimidazole carbamates, albendazole is considered as the most effective, although various undesirable side effects were reported (Reuter et al, 2000), what happened in our case 2. Mebendazole has a lower oral bioavailability and consequently lower plasma levels of the active metabolite than ABZ (Dayan, 2003), but the peak plasma levels of benzimidazoles in individual patients depend also on the metabolic capacity of liver parenchymal cells on cytochrome P450 (Rawden et al, 2000). This could markedly influence the drug´s final the-rapeutical effect.…”

Section: Discussionmentioning

confidence: 99%

Clinical and serological study of human alveolar echinococcosis in Slovakia in relation to the outcome of chemotherapy

Kinčeková

Hrčková

Auer³

et al. 2006

Helminthologia

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SummaryAlveolar echinococcosis (AE), caused by proliferating metacestodes of the parasitic fox tapeworm Echinococcus multilocularis, is a life-threatening disease in humans. In this study we report four human cases of AE in Slovak Republic with regard to various clinical manifestations and susceptibility to chemotherapy with albendazole or mebendazole. Patients were monitored serologically by ELISA test and Western Blots within 2 -5 years after initiation of chemotherapy/surgery. Using computerized tomography (CT) we compared morphological changes of the parasitic lesions in the liver during the course of treatment. The parasitic lesions in the CT were manifested as nodular hyperplasia with hyper or hypodense zones and calcified foci within the lesion. In other cases the lesion was visualised as a hypodense poorly-delineated septated focus without calcifications. In the last case, the diagnosis of AE was confirmed only at surgery. Calcified foci found inside the main parasitic lesions were the only abnormality that was detected in two cases and were absent in other two cases. The levels of specific anti-parasitic antibodies followed the pathomorphological changes in the livers. Total IgG levels to Em2+ and EmP antigen declined gradually during the follow-up (1 -5 years) and disappeared only in the patient receiving radical surgery (cured). In comparison with total IgG, concentration of the IgG4 antibody subclass seemed to correlate more adequately with the outcome of therapy as their levels decreased in improved/stabilised patients, but were elevated in "aggravated" patients. We showed that, in patients with AE in Slovakia, radical surgery of parasitic foci proved to be the most successful treatment and, in inoperable cases, albendazole and mebendazole were differently effective. Moreover, IgG4 levels rather than total IgG to protoscoleces antigens proved to be more sensitive serological marker of the progress of therapy.

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Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics

Cited by 316 publications

References 29 publications

Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model

Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model

Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel

Clinical and serological study of human alveolar echinococcosis in Slovakia in relation to the outcome of chemotherapy

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