Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression

Wang, Liangjun; Liou, Li-Ren; Shi, Yijun; Chiou, Jing-Ting; Lee, Yuan–Chin; Huang, Chin-Wei; Huang, Po‐Wei; Chang, Long‐Sen

doi:10.3390/ijms21113907

Cited by 8 publications

(5 citation statements)

References 40 publications

(64 reference statements)

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“…There is substantial interest in developing senolytic therapies to treat diseases that are associated with age. ABT 263 is of great clinical interest since it was initially used to treat various forms of cancer [88][89][90][91] and has effect on most peripheral tissues, but must be primed with additional drugs in order to affect brain tumors [92,93].…”

Section: Discussionmentioning

confidence: 99%

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Mehdipour

Skinner

et al. 2020

GeroScience

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Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) that resets signaling milieu to a pro-regenerative state through dilution of old plasma, enhanced the health and repair of the muscle and liver, and promoted better hippocampal neurogenesis in 2-year-old mice (Mehdipour et al., Aging 12:8790–8819, 2020). Here we expand the rejuvenative phenotypes of NBE, focusing on the brain. Namely, our results demonstrate that old mice perform much better in novel object and novel texture (whisker discrimination) tests after a single NBE, which is accompanied by reduced neuroinflammation (less-activated CD68+ microglia). Evidence against attenuation/dilution of peripheral senescence-associated secretory phenotype (SASP) as the main mechanism behind NBE was that the senolytic ABT 263 had limited effects on neuroinflammation and did not enhance hippocampal neurogenesis in the old mice. Interestingly, peripherally acting ABT 263 and NBE both diminished SA-βGal signal in the old brain, demonstrating that peripheral senescence propagates to the brain, but NBE was more robustly rejuvenative than ABT 263, suggesting that rejuvenation was not simply by reducing senescence. Explaining the mechanism of the positive effects of NBE on the brain, our comparative proteomics analysis demonstrated that dilution of old blood plasma yields an increase in the determinants of brain maintenance and repair in mice and in people. These findings confirm the paradigm of rejuvenation through dilution of age-elevated systemic factors and extrapolate it to brain health and function.

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Section: Discussionmentioning

confidence: 99%

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Mehdipour

Skinner

et al. 2020

GeroScience

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“…Apoptosis or cell programmed death is also a body standard mechanism to eliminate abnormal and unwanted cells and prevent tissues from becoming cancerous. Apoptotic activator drugs in the body seem to be good options for cancer therapy (20,21). Patel et al (2011) examined and compared the benzimidazole effect alone and in combination with radiotherapy on the viability of MM and SCLC colonic cell lines and showed that benzimidazole sensitizes these cell lines to radiation and its combination with radiation can be a potent treatment for MM and SCLC metastasis into the brain (18).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Effects of Flubendazole in Human Lung Cancer Cell Line A549

Hoveizi

Jahromi

2020

Jentashapir J Cell Mol Biol

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Background: The development of effective anticancer drugs is a significant health issue. Previous studies showed that members of the benzimidazole family have anticancer effects on several cancers Objectives: The present study investigated the cytotoxic effect of flubendazole on A549 human lung cancer cells. Methods: The A549 cells were treated with flubendazole at 1, 2, 5, and 10 µM concentrations for three days. Cell viability was measured by the MTT assay and Acridine orange staining. Also, the expressions of P62 and Beclin -1 were analyzed by qRT-PCR analysis. Results: Cell viability of A549 cells, in a concentration-dependent manner, showed significant differences between the treatment and control groups, and the IC50 value was determined to be 2 µM. Also, flubendazole reduced the expression of P62 and increased the expression of Beclin 1 in treated cells. Conclusions: Flubendazole induces cell death in A549 cells in a dose and time-dependent manner and can offer new factors in lung cancer therapeutic strategies.

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“…Subsequently, ABZs could upregulate SIRT3 expression, which is believed to regulate SOD2 activity to clear mitochondrial reactive oxygen species (ROS). They further speculated that this ability allowed ABZs to protect cancer cells from cytotoxicity in the short-term, but when SIRT3 expression was further reduced, this unique ABZ mechanism was no longer effective ( 54 , 55 ).…”

Section: Progress On the Use Of Benzimidazole Antiparasitic Drugs For Treating Cancermentioning

confidence: 99%

Repositioning of Antiparasitic Drugs for Tumor Treatment

Zheng

Liu

et al. 2021

Front. Oncol.

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Drug repositioning is a strategy for identifying new antitumor drugs; this strategy allows existing and approved clinical drugs to be innovatively repurposed to treat tumors. Based on the similarities between parasitic diseases and cancer, recent studies aimed to investigate the efficacy of existing antiparasitic drugs in cancer. In this review, we selected two antihelminthic drugs (macrolides and benzimidazoles) and two antiprotozoal drugs (artemisinin and its derivatives, and quinolines) and summarized the research progresses made to date on the role of these drugs in cancer. Overall, these drugs regulate tumor growth via multiple targets, pathways, and modes of action. These antiparasitic drugs are good candidates for comprehensive, in-depth analyses of tumor occurrence and development. In-depth studies may improve the current tumor diagnoses and treatment regimens. However, for clinical application, current investigations are still insufficient, warranting more comprehensive analyses.

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Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression

Cited by 8 publications

References 40 publications

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Cytotoxic Effects of Flubendazole in Human Lung Cancer Cell Line A549

Repositioning of Antiparasitic Drugs for Tumor Treatment

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