Albendazole in neurocysticercosis

Kapil, Dinesh; Vohra, Pankaj

doi:10.1007/bf02860518

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2016

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“…13 Albendazole (ABZ) is a broad spectrum anthelminthic drug used primarily in the treatment of echinococcosis and neurocysticercosis. 14 Recent reports reveal its efficacy as a sensitizer in combination with bortezomib, for the treatment of multiple myeloma. 15 Current literature reports its efficacy in cancer chemotherapy in animal models, both as a sensitizer in combination with other anticancer drugs and alone as a chemotherapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

Crystal engineered albendazole with improved dissolution and material attributes

et al. 2016

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Albendazole (ABZ) is a broad spectrum anthelminthic drug and is in the WHO list of essential medicines. It is a "brick dust" drug with very poor water solubility (0.2 pg ml −1 at 25 °C). In the present study, crystal engineering of ABZ was carried out using two different techniques: solvent recrystallization and spherical agglomeration. All the modified habits have shown improved dissolution and flow properties. Spherical agglomerates with HPC as a binder have shown a 5.60 fold enhancement in dissolution efficiency at the end of 6 h when compared to ABZ. The agglomerates with binder showed good compressibility and can be successfully used for direct tabletting.

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Section: Introductionmentioning

confidence: 99%