ALAS2 overexpression alleviates oxidative stress-induced ferroptosis in aortic aneurysms via GATA1 activation
Yunjun He,
Xiaohui Wang,
Donglin Li
et al.
Abstract:Background
Aortic aneurysm, characterized by abnormal dilation of the aorta, poses significant health risks. This study aims to investigate the interaction between 5-aminolevulinate synthase 2 (
ALAS2
) and GATA-binding protein 1 (
GATA1
) in ferroptosis and oxidative stress responses in aortic aneurysm.
Methods
A weighted gene co-expression network analysis (WGCNA) was performed on the differentially expressed genes… Show more
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