Alarm features and age for predicting upper gastrointestinal malignancy in Chinese patients with dyspepsia with high background prevalence of Helicobacter pylori infection and upper gastrointestinal malignancy: an endoscopic database review of 102 665 patients from 1996 to 2006

Bai, Yu; Li, Zhao‐Shen; Zou, Duowu; Wu, Ren-pei; Yao, Yin-zhen; Jin, Zhendong; Ye, Ping; Li, Shude; Zhang, Wenjun; Du, Yiqi; Zhan, Xianbao; Liu, Feng; Gao, Jun; Xu, Guofan

doi:10.1136/gut.2009.192401

Cited by 72 publications

(89 citation statements)

References 37 publications

(38 reference statements)

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“…In addition, patients suffering from biliary and pancreatic diseases accounted for a large proportion and there were several reasons: firstly, our department is particularly specialized in biliary and pancreatic disorders, which might attract a great proportion of patients. Secondly, the incidence of gastrointestinal tumors was not as high as reported, which was supported by our previous researches [18,19]. Besides, the number of patients The prognosis of early GC is better with a 90% 5-year survival rate, while the advanced GC is relatively poor [20].…”

Section: Discussionsupporting

confidence: 59%

WITHDRAWN: Diagnostic performance of carbohydrate antigen 72-4 for gastrointestinal malignancy screening in Chinese patients: a prospective study

Wang¹,

Yu²,

Mao³

et al. 2017

Oncotarget

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Background: Over the past decades, carbohydrate antigen 72-4 (CA72-4) was considered as a tumor marker that was elevated in normal people and patients with malignancies, including gastrointestinal malignancies, ovarian malignancies, endometrium malignancies, lung malignancies and so on. Besides, researches showed that elevated serum CA72-4 might predict digestive tumors, especially gastric tumors, although there was still neither sensitive nor specific tumor biomarker for gastric cancer.Aim: This study was aimed to evaluatethe diagnostic accuracy of CA72-4 in predicting malignancies, especially the gastric cancer.Result: The positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of CA72-4 for diagnosing gastric cancer were 69.7%, 95.9%, 1.70, and 0.97, respectively. In the Receiver Operating Characteristic analysis (ROC),the area under the curvewas 0.62 for discriminating patients with gastric cancer from those without.Conclusions: It is of little significance to perform CA72-4 testalone for predicting malignances, especially gastric cancer, in digestive disease patients.Methods: Four hundred and three patients underwent CA72-4 test after admission to the Department of Gastroenterology in Changhai Hospital, the Second Military Medical University, from June 1, 2015 to October 31, 2015. Data of age, sex, main symptoms and final diagnosis were summarized.

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Section: Discussionsupporting

confidence: 59%

WITHDRAWN: Diagnostic performance of carbohydrate antigen 72-4 for gastrointestinal malignancy screening in Chinese patients: a prospective study

Wang¹,

Yu²,

Mao³

et al. 2017

Oncotarget

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“…2 In Asia, the prevalence of Helicobacter pylori infection and upper GI malignancies are substantially high. 3,4 However, among…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] However, "H. pylori test and treat" was unlikely to be beneficial in the high H. pylori positive area in aspect of cost-effectiveness. 3 This large scale meta-analysis was conducted on the basis of evidence-based medicine in the context of the insufficient existing data and authors clearly revealed important epidemiologic features. The malignancy detection rate in this study was significantly higher than that in Western countries (1.3% vs 0.25%).…”

Section: Commentsmentioning

confidence: 99%

Systematic Review With Meta-analysis: Prompt Endoscopy As the Initial Management Strategy for Uninvestigated Dyspepsia in Asi(Aliment Pharmacol Ther 2015;41:239-252)

Jung

2015

J Neurogastroenterol Motil

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SummaryDyspepsia is a common gastrointestinal (GI) symptom with 10-20% of the population in the Asia-Pacific region. Asian patients with uninvestigated dyspepsia, the diagnostic value of alarm features and the appropriateness of prompt endoscopy are remained uncertainly. Chen et al 5 performed a systematic review to evaluate the detection rate of organic diseases including upper GI malignancies and then to propose the proper initial diagnostic strategy in Asian dyspepsia patients. Among 2410 possible references, finally 18 papers (n = 152 314) were included in the analysis of detection of organic disease by endoscopy among dyspeptic patients. This study revealed that overall malignancy detection rate was 1.3% (95% confidence interval 0.8-2.1%) and among cancer patients, 17.8% were younger than 45 years, 5.0% at age＜ 40 years and 3.0% at age ＜ 35 years. The calculated detection rate of all organic diseases was 26.4% and that of peptic ulcer disease was 11.9% and esophageal disease was 5.5%. However, alarm features were shown to yield moderate diagnostic accuracy with an area under curve of 0.74. It meant limited accuracy for predicting malignancy. Therefore, authors concluded that an age of 35 years yielded relatively better diagnostic accuracy for malignancy.

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“…The prevalence of peptic ulcer disease confirmed endoscopically could reach to 17.2 % [113] in China, substantially higher than in Western populations. Gastric cancer remains the fourth most common malignancy and the second leading cause of cancer mortality in the world [114].…”

Section: Introductionmentioning

confidence: 97%

The Current Main Types of Capsule Endoscopy

Li¹,

Carter²,

Eliakim³

et al. 2014

Handbook of Capsule Endoscopy

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Alarm features and age for predicting upper gastrointestinal malignancy in Chinese patients with dyspepsia with high background prevalence of Helicobacter pylori infection and upper gastrointestinal malignancy: an endoscopic database review of 102 665 patients from 1996 to 2006

Cited by 72 publications

References 37 publications

WITHDRAWN: Diagnostic performance of carbohydrate antigen 72-4 for gastrointestinal malignancy screening in Chinese patients: a prospective study

WITHDRAWN: Diagnostic performance of carbohydrate antigen 72-4 for gastrointestinal malignancy screening in Chinese patients: a prospective study

Systematic Review With Meta-analysis: Prompt Endoscopy As the Initial Management Strategy for Uninvestigated Dyspepsia in Asi(Aliment Pharmacol Ther 2015;41:239-252)

The Current Main Types of Capsule Endoscopy

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