2013
DOI: 10.1016/j.intimp.2013.05.004
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Alanyl-glutamine administration suppresses Th17 and reduces inflammatory reaction in dextran sulfate sodium-induced acute colitis

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Cited by 20 publications
(23 citation statements)
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“…This observation is much difference from the previous reports that arginine or glutamine supplementation significantly lowers these cytokines production [8], [9], [23]. The explanation for this difference remains unknown; perhaps it is related to the high dose of arginine (1.5% in diet) or glutamine (2.0% in diet) supplementation.…”
Section: Discussioncontrasting
confidence: 71%
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“…This observation is much difference from the previous reports that arginine or glutamine supplementation significantly lowers these cytokines production [8], [9], [23]. The explanation for this difference remains unknown; perhaps it is related to the high dose of arginine (1.5% in diet) or glutamine (2.0% in diet) supplementation.…”
Section: Discussioncontrasting
confidence: 71%
“…Previous study reported that DSS causes weight loss in mice [8]. Thus, this study also calculated the average weight gain (AWG) from day 1 to 12.…”
Section: Resultsmentioning
confidence: 99%
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“…Therefore bioactive peptides have the potential to be used as an alternative therapy for IBD and other chronic inflammatory disorders. According to Hou et al[ 106 ], treatment with alanyl-glutamine in a mouse model of colitis suppressed Th-17 cytokines and macrophage migration to the peritoneal cavity, indicating a reduction in the inflammatory response. Propionyl-L-carnitine, an essential factor of transporting fatty acids in mitochondria reduced mucosal inflammation through antioxidative effects in TNBS-induced colitis[ 107 ].…”
Section: Functional Foods and Nutraceuticals For Ibdmentioning
confidence: 99%
“…In mice, IL-17 is essential for host defense against S . aureus infections of the skin [ 21 ] and inhibition of IL-17 is associated with development of acute colitis after exposure to dextran sulfate sodium [ 22 ]. In humans, reduced levels of Th17 cells lead to increased susceptibility to S .…”
Section: Discussionmentioning
confidence: 99%