“…For instance, nanocarriers have emerged as a promising tool for mtDNA targeting, as they offer an optimal platform for drug delivery and facilitate mitochondrial accumulation. They can physically encapsulate insoluble drugs to achieve controlled drug release, ultimately improving drug metabolism and reducing systemic drug toxicity ( Luo et al, 2022 ). Moreover, other molecule-based, polymer-based, lipid-based and peptide-based nano-carrier systems have also been applied in this field, contributing to the advancement of cancer therapy.…”