Alanine Transaminase Level in a Healthy Population in Morocco

Laouina, A.; Abouyoub, Ahmed; Soulaymani, Abdelmajid; Alami, Ramzi S.

doi:10.3923/pjbs.2012.238.243

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Similar prevalence was found in the Casablanca BD (Baha et al 2013). These results were predictable since the hepatitis B incidence in the overall Moroccan population declined from 24·8 in 1999 to 3·2 in 100 000 citizen in 2010 (Santé en chiffre, 2010, Laouina et al, 2012). The most probable explanation for the decrease in the prevalence of HBsAg among BD in Morocco is the introduction of the HBV vaccination.…”

Section: Rabat Bd' Hepatitis B Surface Prevalencementioning

confidence: 96%

Hepatitis B in Moroccan blood donors: a decade trend of the HBsAg prevalence in a resources limited country

Adouani

Alami²,

Laouina

et al. 2013

Transfusion Medicine

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Section: Rabat Bd' Hepatitis B Surface Prevalencementioning

confidence: 96%

Hepatitis B in Moroccan blood donors: a decade trend of the HBsAg prevalence in a resources limited country

Adouani

Alami²,

Laouina

et al. 2013

Transfusion Medicine

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“… 7 , 25 , 33 , 44 The study participants were among healthy blood donors or liver donors in 15 studies. 13 , 19 - 21 , 23 , 24 , 31 , 32 , 34 , 35 , 37 - 39 , 46 , 59 …”

Section: Resultsmentioning

confidence: 99%

Upper Normal Limits of Serum Alanine Aminotransferase in Healthy Population: A Systematic Review

Kolahdoozan

Moeini

Sepanlou

et al. 2020

Middle East J Dig Dis

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BACKGROUND Measuring serum alanine aminotransferase (ALT) enzyme is a routine clinical test commonly used to evaluate abnormalities in the body in general, and in the liver function in particular. Higher ALT levels are associated with some metabolic disorders. The upper limit normal (ULN) is considered as a reliable threshold for the definition of high ALT. OBJECTIVES: To assess the existing evidence on the ULN for ALT in the general population. DATA SOURCE: PubMed (Medline), EMBASE, Scopus, and Web of Science (ISI) were searched using a specified search strategy. ELIGIBILITY CRITERIA: We collected documents published from 1980 to 2018 in the English language, focusing on human samples at the population level and extracted the data after qualitative evaluation. METHODS We conducted this study in accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. We used specific search terms and their combinations to find documents from relevant databases. We used a snowballing approach to find documents not captured in the main phase of the search. Two authors separately conducted the search, screened the articles, and selected documents that were qualified for data extraction based on the defined inclusion criteria. Finally, data extraction was conducted by two authors using PRISMA checklist. Reported ULNs for ALT and 95% confidence intervals (CIs) were documented in previously developed datasheets. RESULTS Out of 15242 studies, 47 articles were included for data extraction and analysis. Data were sparse and lacked the consistency to precisely estimate ULN for serum ALT. The ULN of ALT was significantly diverse across various geographical locations and sexes. The lowest value of ULN for ALT was 19 IU/L in Chinese children (age range: 7 to < 10 years), and the highest value of ULN for ALT was 55 IU/L in children from Ghana aged < 5 years. LIMITATIONS: The main limitation of the current systematic review was the scarcity of the reported measures for ULN of ALT. CONCLUSION Based on the results of the current systematic review, it is suggested that the normal range of ALT be redefined, but this redefinition should be done according to the localized data. In order to redefine the ULN for ALT, regional differences, methods used in ALT measurements, and ULN determination should be considered.

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“…These results could be influenced by differences in serum AST and platelet counts between males and females. Females tend to have lower serum AST than males until the ninth decade when the disparity is reversed (Laouina, et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Ast to Platelet Ratio Index (Apri) and Degree of Severity Based on Child-Pugh Classification Among Cirrhosis Patients at Internal Medicine Ward in a Tertiary Hospital

Kurniawan

Widodo

Agustina

2022

MBIOM

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Highlights: 1. The Child-Pugh score is an instrument to assess the degree of severity and prognosis of chronic liver disease. 2. the rise in APRI score may predict the advance of cirrhosis stages. Abstract: Background: Simple diagnostic and screening methods are needed to assist with liver biopsy, which is not always available in local health facilities. Objective: To assess the AST-to-Platelet Count Index (APRI) as a means to predict the advance of cirrhosis stages as indicated in Child-Pugh classification. Material and Method: This research employed an observational descriptive study design to examine laboratory values such as serum AST and platelet count, which were then compared to Child-Pugh profiles among cirrhosis patients at an inpatient facility in a tertiary hospital of Dr Soetomo General Academic Hospital, Surabaya, Indonesia on 1 January – 31 December 2015. The sampling method for this research was total sampling from medical histories. Result: Data obtained were then analyzed and tabulated using the descriptive technique. As many as 191 samples were obtained, consisting of male (N=129, 67.54%) and female patients (N=62, 32.46%) with a ratio of 2.08:1. APRI score showed an increase in age, with a peak frequency of 68 patients (35.6%) in the range 50-59 years old. Male patients had a higher average APRI score (2.11) than their female counterparts (1.93). Patients from Child C were the majority in this research, consisting of 105 patients (54.9%), followed by Child B (N=65, 34.03%) and A (N=21, 10.9%). Conclusion: The proportion of patients with APRI score > 1.5 is increasing along with the degree of severity according to the Child-Pugh classification. This indicates that the rise in APRI score may predict the advance of cirrhosis stages.

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Alanine Transaminase Level in a Healthy Population in Morocco

Cited by 5 publications

References 27 publications

Hepatitis B in Moroccan blood donors: a decade trend of the HBsAg prevalence in a resources limited country

Hepatitis B in Moroccan blood donors: a decade trend of the HBsAg prevalence in a resources limited country

Upper Normal Limits of Serum Alanine Aminotransferase in Healthy Population: A Systematic Review

Ast to Platelet Ratio Index (Apri) and Degree of Severity Based on Child-Pugh Classification Among Cirrhosis Patients at Internal Medicine Ward in a Tertiary Hospital

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