Alanine and lactate as gluconeogenic substrates during late gestation

Cuezva, J M; Valcarce, Carmen; Chamorro, Margarita; Franco, A.; Mayor, Federico

doi:10.1016/0014-5793(86)80088-6

Cited by 16 publications

(5 citation statements)

References 27 publications

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“…Regarding individual amino acids, alanine and glycine accounted for a major proportion of amino acids taken up by the liver, especially in fed pregnant rats. This finding is in accordance with the higher rates of conversion of alanine into glucose found in hepatocytes isolated from fed late-pregnant rats compared with those from fed virgin controls (Cuezva et al, 1986).…”

Section: Substrate Availabilitysupporting

confidence: 89%

Hepatic uptake of amino acids in late-pregnant rats. Effect of food deprivation

Casado

Remesar

Pastor‐Anglada

1987

Biochemical Journal

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Hepatic availability, uptake and fractional extraction of amino acids were estimated in anaesthetized 21-day-pregnant and age-matched virgin rats, either fed or after 24 h starvation. Amino acid availability was unaltered in fed pregnant rats as compared with fed virgin controls. However, the hepatic uptake of these compounds was higher in the former than in the latter. These adaptations were mediated by an increase in the hepatic capability to take up amino acids in late-pregnant rats, as reflected by the changes found for the fractional extraction rates. The decrease in amino acid availability found after starvation was more pronounced in pregnant than in virgin rats. Nevertheless, the hepatic uptake was similar in both groups. These results indicate that amino acids are not limiting for ureagenesis during late pregnancy, strongly suggesting that the mechanism(s) which modulate urea synthesis may be intracellular in origin.

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Section: Substrate Availabilitysupporting

confidence: 89%

Hepatic uptake of amino acids in late-pregnant rats. Effect of food deprivation

Casado

Remesar

Pastor‐Anglada

1987

Biochemical Journal

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“…In contrast, with the progressive insulin-insensitivity that the peripheral organs develop toward the end of pregnancy, the hepatic glucose production remains sensitive to the stimulation of this hormone throughout gestation (Butte, 2000). Gluconeogenesis is limited during gestation, probably to maintain high levels of AA (Butte, 2000;Kalhan et al, 1997), whereas it occurs in some extent at the end of pregnancy as an important homeostatic pathway in the supply of glucose to the growing fetus (Cuezva et al, 1986). Besides the regulation of energy homeostasis, the liver plays another essential role during pregnancy by participating in the elimination of waste molecules accumulated by the embryo metabolism (McArthur et al, 2003;van Herwaarden et al, 2007).…”

Section: Consequences Of Placentation For Female Hepatic Metabolismmentioning

confidence: 95%

Sex Differences: A Resultant of an Evolutionary Pressure?

Torre

Maggi

2017

Cell Metabolism

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“…It has been reported that the human embryo can catabolize amino acids to produce energy [ 33 ]. It is also possible that the catabolic metabolism of amino acids is enhanced, as studies on pregnant rats have shown that tryptophan catabolism is increased in late pregnancy compared with mid-pregnancy [ 34 ]. Unexpectedly, amino acid concentrations in amniotic fluid were positively correlated with maternal lipid intake; conversely, they were negatively correlated with carbohydrate intake.…”

Section: Discussionmentioning

confidence: 99%

Amino Acid Composition of Amniotic Fluid during the Perinatal Period Reflects Mother’s Fat and Carbohydrate Intake

et al. 2021

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Dietary content during pregnancy is important because it is necessary for the growth of the fetus. With the assumption that the nutritional status of the fetus can be monitored by measuring amino acid concentrations in the amniotic fluid, we investigated whether the habitual dietary intake of pregnant women affected the composition of the amniotic fluid and the significance of performing amniotic fluid analysis. The subjects were 34 mothers who delivered full-term babies by cesarean section. Three biological samples were collected from the mothers: blood, cord blood, and amniotic fluid. At the same time, the mothers’ prenatal nutritional intake information was also recorded. When the amino acid contents of the samples were compared with the mothers’ nutrient intake, many amino acids in the amniotic fluid were positively correlated with lipid intake, but not with protein intake. There was a negative correlation between lipid intake and carbohydrate intake, and the amino acid contents of the amniotic fluid were also negatively correlated with carbohydrate intake. The results of this study were consistent with those found in animal models, suggesting that the analysis of amniotic fluid may be a useful method to investigate the effects of habitual diet during human pregnancy on the fetus.

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Alanine and lactate as gluconeogenic substrates during late gestation

Cited by 16 publications

References 27 publications

Hepatic uptake of amino acids in late-pregnant rats. Effect of food deprivation

Hepatic uptake of amino acids in late-pregnant rats. Effect of food deprivation

Sex Differences: A Resultant of an Evolutionary Pressure?

Amino Acid Composition of Amniotic Fluid during the Perinatal Period Reflects Mother’s Fat and Carbohydrate Intake

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