Alanine aminotransferase serum levels in COVID-19 patients inversely correlate with SARS-CoV-2 antigen

Rouka, Erasmia; Kotsiou, Ourania S.; Perlepe, Garyfallia; Pagonis, Athanasios; Pantazopoulos, Ioannis; Gourgoulianis, Konstantinos

doi:10.1097/meg.0000000000002105

Cited by 1 publication

(4 citation statements)

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“…With respect to the biochemical parameters, we have previously reported the inverse correlation of ALT serum levels with the SARS-CoV-2 NP Ag [10], a finding which is reinforced in this study irrespective of patient categorization. e anti-S total Ig levels positively correlated with ALT, LDH, and ferritin in the initial pooled analysis, yet different results were obtained by the group analysis which also showed differences between the two groups in the temporal associations of the SARS-CoV-2 Ag and total Ig levels with creatinine, CRP, lactic acid, and urea.…”

Section: Discussionsupporting

confidence: 79%

“…Several research groups have reported significant higher levels of ferritin in severe COVID-19 patients [25,26]. Intestinal infection with SARS-CoV-2 has been associated with mild inflammatory response possibly due to the induction of potent neutralizing IgA antibodies which are mainly produced in the intestines [19]; thus, the underlying pathophysiological mechanisms of COVID-19-associated liver dysfunction should further be studied in the context of hepatocyte immune function [10]. It has been reported that, by using the machine learning method, research centers could establish accurate prediction models of outcome of SARS-CoV-2 pneumonia based on their laboratory findings [27].…”

Section: Discussionmentioning

confidence: 99%

“…Nasopharyngeal swab and whole blood specimens were collected from each patient every two days since admission, for the semiquantitative determination of the SARS-CoV-2 NP antigen (Ag) and the semiquantification of the IgA, IgM, and IgG (total Ig) spike protein-specific antibodies, respectively, with lateral flow immunochromatographic assays (Catalog numbers: V1310/1330 and V1210/V1230, Prognosis Biotech, Larissa, Greece). This technology has been previously used by our group and the method description partly reproduces our wording [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

“…is technology has been previously used by our group and the method description partly reproduces our wording [10].…”

Section: Laboratory Investigationmentioning

confidence: 99%

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Temporal Associations of the SARS-CoV-2 NP Antigen and Anti-Spike Total Ig Levels with Laboratory Parameters in a Greek Cohort of Hospitalized COVID-19 Patients

Rouka

Kotsiou

Perlepe

et al. 2021

Canadian Respiratory Journal

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Background. The direct effect of SARS-CoV-2 on the lungs results in increased hospitalization rates of patients with pneumonia. Severe COVID-19 patients often develop ARDS which is associated with poor prognosis. Assessing risk factors for COVID-19 severity is indispensable for implementing and evaluating therapeutic interventions. We investigated the temporal associations between the SARS-CoV-2 antigen (Ag), total Immunoglobulin (Ig) levels, and several laboratory parameters in hospitalized patients with varying degrees of COVID-19 severity. Methods. The SARS-CoV-2 nucleocapsid protein (NP) and total Ig Spike (S) protein-specific antibodies were determined for each patient with lateral flow assays through repeated sampling every two days. Hematological and biochemical parameters were evaluated at the same time points. Results. 40 Greek COVID-19 patients (31 males, 9 females) with a median age of 59.50 ± 16.21 years were enrolled in the study. The median time from symptom onset to hospitalization was 8.0 ± 4.19 days. A significant negative correlation was observed between the SARS-CoV-2 Ag and total Ig levels. The temporal correlation patterns of the SARS-CoV-2 NP Ag and anti-S total Ig levels with laboratory markers varied among patients with differing degrees of COVID-19 severity. Severe-critical cases had lower SARS-CoV-2 Ag and increased total Ig levels as compared to mild-moderate cases. Conclusions. Distinct temporal profiles of the SARS-CoV-2 NP Ag and anti-S total Ig levels may distinguish different groups of COVID-19 severity.

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Section: Discussionsupporting

confidence: 79%