Alanine Aminotransferase and High Sensitivity C-Reactive Protein: Correlates of Cardiovascular Risk Factors in Youth

Oliveira, Antônio Carlos Paula de; Oliveira, Ana Mayra Andrade de; Almeida, Marcele S. de; Silva, Agnaluce M.; Adan, Luís; Ladeia, Ana Marice

doi:10.1016/j.jpeds.2007.07.013

Cited by 34 publications

(39 citation statements)

References 24 publications

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“…With this study, we have shown that BMI is not the only variable that can affect the increase in hs-CRP, unlike what has been described in previous studies (5,6). Therefore, a possible interaction is found between hs-CRP and the levels of triglycerides and HDL-cholesterol, suggesting its utility as a metabolic risk marker (7,8). This interaction between hs-CRP, triglycerides and HDL-cholesterol could be mediated by different cytokines of adipose origin that in some genetically predisposed individuals are elevated in relation to higher abdominal adiposity (1).…”

Section: Resultscontrasting

confidence: 47%

“…However, more prospective studies will be necessary in order to clarify this relationship. The absence of influence of age or Tanner pubertal stage in hs-CRP levels shows the utility of this parameter as a metabolic risk marker in early stages of life (8).…”

Section: Resultsmentioning

confidence: 99%

“…Later studies have shown high values of hs-CRP among obese children and adolescents, indicating that in early stages there already exists a certain level of inflammation in relation to the non-obese population (5)(6)(7)(8). However, not many data are available that guarantee its utility as a marker of cardiovascular risk and diabetes in childhood (7,8).…”

Section: Introductionmentioning

confidence: 99%

“…However, not many data are available that guarantee its utility as a marker of cardiovascular risk and diabetes in childhood (7,8). Therefore, our intention is to study the levels of hs-CRP in obese children and adolescents with and without metabolic syndrome to evaluate the utility of this parameter as a method of early diagnosis of cardiovascular risk in early stages of life and to analyse whether there are variables associated with higher levels of CRP.…”

Section: Introductionmentioning

confidence: 99%

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High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Soriano‐Guillén

Hernández-García

Pita³

et al. 2008

European Journal of Endocrinology

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Objective: We intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents. Methods: The study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism. Results: Out of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8-4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5-2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels. Conclusion: The hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.European Journal of Endocrinology 159 R1-R4

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Section: Resultscontrasting

confidence: 47%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Soriano‐Guillén

Hernández-García

Pita³

et al. 2008

European Journal of Endocrinology

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“…[15][16][17] Obese adolescents with MetS have a fivefold increase in NAFLD compared with obese adolescents without MetS. 17 The link between NAFLD and IR has raised speculation regarding interrelationships between NAFLD and IR, with shared features of visceral obesity (frequently assessed as elevations in waist circumference [WC]), 18 elevated triglycerides, and underlying inflammation, indicated by increases in highsensitivity C-reactive protein (hsCRP) [19][20][21] and g-glutamyl transferase (GGT). 22,23 The tight link between MetS and NAFLD has prompted some to suggest screening for NAFLD (via assessment for unexplained ALT elevations .30 U/L) among adolescents with MetS.…”

Section: E718mentioning

confidence: 99%

Ethnic Differences in the Link Between Insulin Resistance and Elevated ALT

DeBoer

Wiener²,

Barnes

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Evaluating for elevations in alanine aminotransferase (ALT) is a common screening test for the presence of nonalcoholic fatty liver disease (NAFLD). NAFLD is less common among non-Hispanic blacks. Better predictors of NAFLD are needed to identify individuals in most need of screening. WHAT THIS STUDY ADDS:Relative to other ethnicities, metabolic syndrome and insulin resistance performed poorly at identifying non-Hispanic black adolescents with ALT elevations. The presence of metabolic syndrome may therefore not be an adequate trigger for NAFLD screening. Triglyceride elevations performed similarly between groups in identifying ALT elevations. abstract BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) exhibits tight links with insulin resistance (IR) and the metabolic syndrome (MetS), a cluster of cardiovascular risk factors. Compared with non-Hispanic whites, non-Hispanic black adolescents have more IR but a lower prevalence of NAFLD and MetS. Our hypothesis was that IR would be a better predictor of alanine aminotransferase (ALT) elevations than is MetS among non-Hispanic blacks. METHODS:We analyzed data from 4124 adolescents aged 12 to 19 years in the 1999 to 2010 NHANES, using unexplained elevations in ALT (.30 U/L) to characterize presumed NAFLD and using a pediatric adaptation of the Adult Treatment Panel III definition of MetS. RESULTS:Prevalence of elevated ALT varied by race/ethnicity (Hispanics 13.7%, non-Hispanic white 8.6%, non-Hispanic blacks 5.4%, P , .0001). Among non-Hispanic whites and Hispanics, a classification of MetS performed well in identifying adolescents with elevated ALT (odds ratios [ORs] 9.53 and 5.56, respectively), as did MetS-related indices. However, among non-Hispanic blacks, the association between MetS and ALT elevations was smaller in magnitude and technically nonsignificant (OR = 3.24, P = .051). Furthermore, among non-Hispanic blacks, the presence of IR and elevated waist circumference performed more poorly at identifying ALT elevations (ORs 3.93 and 2.28, respectively: significantly smaller than ORs for non-Hispanic whites, P , .05), with triglyceride elevations being a better predictor (OR = 4.44).CONCLUSIONS: Non-Hispanic black adolescents exhibit a lower relationship between IR and elevated ALT, supporting racial/ethnic differences in the link between MetS and NAFLD. These data may have implications regarding triggers for screening for NAFLD among nonHispanic black adolescents, focusing particularly on those with triglyceride elevations. Pediatrics 2013;132:e718-e726 KEY WORDS metabolic syndrome, visceral obesity, inflammation, racial/ethnic difference ABBREVIATIONS ALT-alanine aminotransferase BP-blood pressure GGT-g-glutamyl transferase HDL-C-high-density lipoprotein cholesterol HOMA-IR-homeostasis model of insulin resistance hsCRP-high-sensitivity C-reactive protein IR-insulin resistance MetS-metabolic syndrome NAFLD-nonalcoholic fatty liver disease OR-odds ratio WC-waist circumference Drs DeBoer, Wiener, and Barnes were involved in th...

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High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

Tabatabaeizadeh

Rezayi

Bahrami

et al. 2017

J of Cellular Biochemistry

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The prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease, and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C-Reactive Protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls. A total of 580 adolescent girls were recruited follow by evaluation of CRP and hematological parameters before and after supplementation with vitamin D supplements as 9 of 50000 IU cholecalciferol capsules for 9 weeks taken at weekly intervals. At baseline, serum hs-CRP level was 0.9 (95%CI: 0.5-1.8), while this value after intervention was reduced to 0.8 (95%CI: 0.3-1.6; P = 0.007). Similar results were also detected for NLR (e.g., NLR level was 1.66 ± 0.72 and 1.53 ± 0.67, P = 0.002, before and after therapy with compliance rate of >95.2%). Moreover, we found an association between hs-CRP and BMI, triglyceride, white blood cell count, and lymphocytes. Interestingly we observed a significant reduction in neutrophil count and CRP level after high dose vitamin D supplementation. Our findings showed that the high dose supplementation of vitamin D affects measures of systemic inflammation: reductions in High Sensitivity C-Reactive Protein level and Neutrophil-to-lymphocyte ratio (NLR) distribution. J. Cell. Biochem. 118: 4317-4322, 2017. © 2017 Wiley Periodicals, Inc.

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Alanine Aminotransferase and High Sensitivity C-Reactive Protein: Correlates of Cardiovascular Risk Factors in Youth

Cited by 34 publications

References 24 publications

High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Ethnic Differences in the Link Between Insulin Resistance and Elevated ALT

High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

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