Untitled

Abstract

Energy dispersive X-ray fluorescence technique was employed to study the interactions among various elements, viz.: K, Zn, Br, Fe, Cu, Br & Rb in 4 groups of rats viz. control-GI, diabetic-GII (diabetes induced by i.p. administration of alloxan monohydrate at a dose level of 150 mg/kg b.w; single injection), lithium treated-GIII (lithium administered as Li2 Co3 at a dose level of 1.1 g of Li2 Co3/kg animal diet; free access; serum lithium levels--0.5-1.2 mEq/L) and lithium + diabetic rats-GIV. The different treatments continued for a total duration of 1 month. The K contents were found to be significantly lowered in all the treatment groups which was maximum (28%) in lithium treated diabetic rats. Depression in the levels of Rb was noticed in lithium treated and lithium treated diabetic (G-III and G-IV) groups. However, the levels (Rb) remained unaltered in diabetic (G-II) group. Interestingly, a significant decline was observed in Fe levels in G-III following lithium administration but the levels remained unchanged in G-IV with lithium administration to diabetic rats. On the other hand, lithium treatment to normal (G-III) and diabetic (G-IV) rats indicated statistically significant elevation in the levels of Cu and Br. However, diabetic (G-II) rats did not indicate any elevation in the levels of these two elements. Interestingly, the concentrations of Zn were found to be significantly elevated in all the treatment groups, which was maximum (37%) in G-III (lithium) group. A comparison of various elements from lithium treated diabetic group G-IV with the corresponding elements from the diabetic group G-II, implied a significant depression in K and Rb levels and a significant elevation in the levels of Br.

Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

“…In the present study, serum iron as well as mean corpuscular haemoglobin was slightly decreased in the lithium-treated group, and selenium co-administration seemed to exert a slight beneficial effect. Dhawan et al also observed depressed iron in lithium-administered rats [45]. As the period of our experiment was rather short, further studies could allow the clarification of the issue on whether lithium administration could disturb iron homeostasis and whether selenium might alleviate such effect.…”

The neuroprotective effect of lithium against high dose methylphenidate: Possible role of BDNF

“…Lithium is used for the treatment of bipolar disorder, via the inhibition of glycogen synthase kinase-3β enzyme (GSK-3β) (Lenox andHahn, 2000, Phiel andKlein, 2001). Many clinical and experimental studies showed that lithium from ranges 10 to 400 mg/kg caused neuroprotection in different conditions (Boyko et al, 2015, Chrislip et al, 1984, Dhawan et al, 1999, Frey et al, 2006, Hajek and Weiner, 2016, Khairova et al, 2012, Machado-Vieira et al, 2009, Rahimi et al, 2014, Rahimi_Balaei et al, 2010. Several clinical reviews showed that optimum lithium concentration after therapeutic doses is 0.6-0.75 mmol/L.…”

“…The selection of doses of MPH was done according to previous work results on neurodegenerative doses of MPH in animal models and human subjects (Balcioglu, Ren, 2009, Gerasimov, Franceschi, 2000, Hannestad, Gallezot, 2010, Motaghinejad, Motevalian, 2015e, Quinn, Wigal, 2004, Schiffer, Volkow, 2006, Teo, Stirling, 2002, Thanos, Robison, 2015, Volkow, Wang, 2001, Wargin, Patrick, 1983, and neuroprotective doses of lithium was obtained from previous work on human and animal studies (Boyko, Nassar, 2015, Chrislip, Anger, 1984, Dhawan, Singh, 1999, Frey, Valvassori, 2006, Hajek and Weiner, 2016, Khairova, Pawar, 2012, Machado-Vieira, Manji, 2009, Rahimi, Dehpour, 2014, Rahimi_Balaei, Momeny, 2010. There are several references in relation to clinical relevance of choosing MPH and lithium doses in our experiment, and also the relationship that exist between doses and plasma levels in experimental subjects (Balcioglu, Ren, 2009, Hanak, Chevillard, 2014, Morrison, Pritchard, 1971, Severus, Kleindienst, 2007, Severus, Kleindienst, 2008, Teo, Stirling, 2002, Thanos, Robison, 2015, Wargin, Patrick, 1983 Elevated Plus Maze (EPM) was used to assess anxiety in animal models.…”

Mechanical properties of metal oxide dispersed jute fiber reinforced polyester biocomposites

“…But growing environmental concern, health, safety, and biodegradability issues of synthetic fibers forced the designer to think on natural fiber reinforced composites (FRCs). Moreover, natural fibers are cheap and lighter in weight . Tactfully modification of interface enables these natural fiber filled composite to compete with the synthetic ones .…”