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Ismailova, M. G.; Makhkamov, Kh. M.; Ismailova, P. L.

doi:10.1023/a:1010460020089

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“…Previously, we have developed [4] a technology for obtaining activated charcoal for medicinal applications from (AU-L grade) from cotton lignin, a readily available local raw plant material. The results of physicochemical and pre-liminary clinical investigations showed that the AU-L charcoal possessed a large specific surface (S sp = 1270 m 2 /g), had a developed porous structure (total pore volume V S = 1 -46 cm 3 /g; total micropore volume M mic = 0.445 cm 3 /g; total mesapore volume M mes = 0.178 cm 3 /g; total macropore volume M mac = 0.423 cm 3 /g), and exhibited high sorption activity with respect to some toxic metabolites.…”

Section: Methodsmentioning

confidence: 99%

Technology of activated charcoal (AU-L) tablets and their sorption capacity determination

Ismailova

2007

Pharm Chem J

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A new technology is developed for the production of activated charcoal (AU-L) tablets from cotton lignin, a readily available local raw plant material. The physicochemical and technological properties of the parent substance (powder) have been studied and the optimum composition of tablets has been determined. The best technological characteristics of both the initial mass and the ready-to-use tablets are achieved for the composition involving a 3% methyl cellulose gel as a binding component and microcrystalline cellulose as a filler. The qualitative characteristics of AU-L tablets have been studied and their sorption capacity has been determined.The new technology will be implemented at the Tashkent Pharmaceutical Plant (Uzfarmprom Company).The development of most pathological processes in the organism is accompanied by intoxication symptoms. The most effective means of treatment of such states is efferent therapy aimed at the recovery and maintenance of the natural systems and functions of the organism [1]. In this context, a special role is played by enterosorption, which showed good results owing to the well-pronounced detoxicating action. This approach is advantageous to other methods of therapy in being simple, having no couterindications, and leading to no complications [2]. Enterosorption can be effected using various sorbents, which differ in their structure, nature, and form of the material. The most readily available nonspecific sorbents are activated charcoals, which possess a well developed surface (up to 1000 m 2 /g) and are capable of binding large amounts of toxic substances by means of nonspecific van der Waals interaction [3]. The main method of control over the selectivity of activated charcoals is based on the modification of their porous structure, which can be achieved by selecting the raw material type and changing the preparation conditions. MATERIALS AND METHODSPreviously, we have developed [4] a technology for obtaining activated charcoal for medicinal applications from (AU-L grade) from cotton lignin, a readily available local raw plant material. The results of physicochemical and pre-liminary clinical investigations showed that the AU-L charcoal possessed a large specific surface (S sp = 1270 m 2 /g), had a developed porous structure (total pore volume V S = 1 -46 cm 3 /g; total micropore volume M mic = 0.445 cm 3 /g; total mesapore volume M mes = 0.178 cm 3 /g; total macropore volume M mac = 0.423 cm 3 /g), and exhibited high sorption activity with respect to some toxic metabolites. It was established that AU-L could be used in medicine as an effective enterosorbent.This study was devoted to developing a commercial technology for the production of AU-L tablets as the most convenient medicinal form RESULTS AND DISCUSSIONThe results of preliminary investigation of the physicochemical and technological properties of the parent substance (powder) of AU-L charcoal gave rather contradictory results. The substance proved to be highly elastic and could not be processed by direct molding, whic...

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Section: Methodsmentioning

confidence: 99%