Al-MCM-41 as a mild and ecofriendly catalyst for Michael addition of indole to α,β-unsaturated ketones

Chemoselective aza-Michael addition of indoles to 2-aroyl-1,3-diarylenones

“…However, the reported reactions of indole with enones generally take place at the C3 or C2 positions. [29][30][31][32][33][34][35][36][37] There is scant literature on the aza-Michael addition reactions at the N1 position. 38,39 2-Aroyl-1,3-diarylenones have many important applications in organic synthesis.…”

Supported Ionic Liquid H2PMo12O40-NMPIL@SiO2 as an Efficient Catalyst for Alkylation of Indoles with Epoxides or Alcohols under Mild Conditions

“…However, these protocols suffered from some drawbacks such as the use of stoichiometric amount of Lewis acid and generation of vast amounts of corrosive wastes. In order to overcome these problems, many efforts have been developed for the catalytic alkylation of indoles, and various compounds were used as nucleophiles including imines [8,9], nitroalkenes [10,11], ketones [12][13][14][15], aldehydes [16,17], epoxides [18][19][20][21], alcohols [22][23][24][25], N-Boc aminals [26], 2-enoylpyridine-N-oxides [27], p-quinols [28], and others [29][30][31][32][33]. Among these nucleophiles, epoxides and alcohols have attracted more interesting owing to the fact that their alkylation reactions with indoles are atom economic [18][19][20][21][22][23][24][25].…”

Post-modified anionic nano-porous metal–organic framework as a novel catalyst for solvent-free Michael addition reactions

“…However, most of them were Lewis acids. [8][9][10] Solid base catalysts have been scarcely explored for application in the Michael addition of pyrrole to nitroolens. Because of rather modest basicity of these heterogeneous systems, chemoselectivity is more controllable in the reaction.…”