An 80-year-old woman who presented with epigastralgia was found having a swollen, wall-Thickenedgallbladderwithpericholecysticfluidretentioninabdominalcontrast-enhancedCTscan.Shewas diagnosedwithacutecholecystitiswithperforationandunderwentemergencylaparoscopiccholecystectomy.Histopathologyrevealedinfiltrationofinflammatorycellsalongwithnecrosisinthegallbladderwall andamyloiddepositiontothearteriolarwallthatwouldcausearteriolarobstruction.Fromthesefindings, arteriolarobstructionduetoamyloiddepositionmightbeoneofthecausesofacuteacalculouscholecystitisinthiscase.Herpostoperativecoursewasuneventfulandshewasdischargedfromourhospitalonthe 11 th postoperativeday.