Akute Thalliumvergiftung

Thallium poisoning. Diagnosis may be elusive but alopecia is the clue.

“…This effectively reduces enteric reabsorption of thallium, thus enhancing faecal excretion. The elimination half life of thallium without treatment is about eight days'5 16 and about three days with Berlin blue. Charcoal haemoperfusion and haemodialysis may be helpful if given within 48 hours after ingesting thallium as these treatments act only in the distribution phase.…”

Alkaline Hydrolysis of 1,3-Dimethylphenobarbital

“…Unlike I-methylphenobarbital and phenobarhital itself (7), I alkaline hydrolysis yielded only the substituted diamide IV. Although this compound could be the result of decarboxylation of a carbamic acid intermediate formed by a 1,2-ring opening, the acid intermediate actually isolated was identified as a malonuric acid formed by a 1,6-ring opening.…”

“…The overall irreversibility of IV hydrolysis was due to the decarboxylation of a carbamic acid, which was too unstable to isolate. Phenobarbital and its N-methyl derivative yielded acetylureides and diamides, but no malonuric acids (7), upon hydrolysis. The simplicity of I hydrolysis is due to dimethylated diamide and malonuric acid stability.…”

“…1,3-Dimethyl-5,5-disubstituted barbituric acid hydrolysis yielded only the N,N'-dimethylmalondiamides (6). Neither a malonuric acid nor a carbamic acid was isolated from the hydrolysis of phenobarbital, its N-methyl derivative (7), and 1,3-dimethylphenobarbital (6). A diamide was the main product in 1,3-dimethylbarbital alkaline hydrolysis, which also produced an acid intermediate.…”

Synthesis and Hypotensive Activity of a Series of 2-Substituted 5,6-Dimethoxyindazoles

“…Aldrich. 5 Mallinckrodt Chemical Works. 6 Both standard solutions are stable at room temperature for at least 4 weeks.…”