Akute Psychose nach Konsum von synthetischen Cannabinoiden

Mörkl, Sabrina; Blesl, C.; Wurm, Walter; Tmava, A.

doi:10.1055/s-0042-103425

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…This implies that the risks of newer SCs to produce strong psychotomimetic effects are higher compared with JWH-018. This seems to be supported by some anecdotal case and hospital reports (Mörkl et al 2016;Hermanns-Clausen et al 2018). There is an urgent need for more controlled experimental studies to follow up on these developments in the drug market.…”

Section: Discussionmentioning

confidence: 94%

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis

et al. 2021

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Background Synthetic cannabinoids (SCs) are the largest class of novel psychoactive substances (NPS) and are associated with an increased risk of overdosing and adverse events such as psychosis. JWH-018 is one of the earliest SCs and still widely available in large parts of the world. Controlled studies to assess the safety and behavioural profiles of SCs are extremely scarce. Aim The current study was designed to assess the psychotomimetic effects of a moderate dose of JWH-018. Methods Twenty-four healthy participants (10 males, 14 females) entered a placebo-controlled, double blind, within-subjects trial and inhaled vapour of placebo or 75μg/kg bodyweight JWH-018. To ascertain a minimum level of intoxication, a booster dose of JWH-018 was administered on an as-needed basis. The average dose of JWH-018 administered was 5.52 mg. Subjective high, dissociative states (CADSS), psychedelic symptoms (Bowdle), mood (POMS) and cannabis reinforcement (SCRQ) were assessed within a 4.5-h time window after drug administration. Results JWH-018 caused psychedelic effects, such as altered internal and external perception, and dissociative effects, such as amnesia, derealisation and depersonalisation and induced feelings of confusion. Conclusion Overall, these findings suggest that a moderate dose of JWH-018 induces pronounced psychotomimetic symptoms in healthy participants with no history of mental illness, which confirms that SCs pose a serious risk for public health.

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Section: Discussionmentioning

confidence: 94%

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis

et al. 2021

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“…For example, in July 2015 a serious outbreak of intoxications and fatalities after the consumption of a synthetic cannabinoid herbal mixture (called "Mocarz", meaning "Strongman") occurred in Poland. More than 200 users were hospitalized with intoxication symptoms, and several deaths have been reported (3)(4)(5)(6). Several different synthetic cannabinoids were identified in "Mocarz" herbal mixtures, and more specifically MDMB-CHMICA seems to have caused a lot of victims (6)(7)(8)(9).…”

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confidence: 99%

Identification of a new tert -leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)

Risseeuw

Blanckaert

Coopman³

et al. 2017

Forensic Science International

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A brown powder and different product packages of "spice-like" herbal incenses were analyzed using a systematic identification approach based on liquid chromatography with diode array detector (HPLC-PDA) and gas chromatography mass spectrometry (GC-MS) with computer based library search against spectral libraries. However, the most predominant compound in the methanolic sample solutions could not be identified. In order to elucidate the chemical structure, a more extensive analysis of the material was initiated using liquid chromatography mass spectrometry (LC-MS), electrospray high resolution mass spectrometry (ESI-HRMS) and H,C and F nuclear magnetic resonance spectroscopy (NMR), which allowed the identification and characterization of the major compound as methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA). The goal of this study is to provide analytical information for the identification of this new tert-leucinate class synthetic cannabinoid by various analytical methods.

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Synthetic Cannabinoid Use

Karila

Benyamina

2018

Cannabis Use Disorders

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Akute Psychose nach Konsum von synthetischen Cannabinoiden

Abstract: Legal highs are a challenge in psychiatric acute care, because they provoke unpredictable mental states endangering self and others.

Cited by 5 publications

References 15 publications

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis

Identification of a new tert -leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)

Synthetic Cannabinoid Use

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