Akute Pankreatitis - unerwünschte Wirkung von 5-Aminosalicylsäure (Mesalazin) in verschiedenen galenischen Applikationsformen

Schwörer, H.; Ramadori, G

doi:10.1055/s-2000-8072

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…The investigators independently screened all articles for those that met broad inclusion criteria. A total of 92 citations were found [1,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,…”

Section: Literature Searchmentioning

confidence: 99%

NSAIDs and Acute Pancreatitis: A Systematic Review

2010

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The resulting pain is the main symptom of acute pancreatitis and it should be alleviated as soon as possible. NSAIDs are the first line therapy for pain and they are generally administered to acute pancreatitis patients upon admission to the hospital. In addition, these drugs have also been used to prevent post-endoscopic cholangiopancreatography (ERCP) acute pancreatitis. On the other hand, there are several reports indicating that NSAIDs may be the actual cause of acute pancreatitis. We carried out a literature search on PubMed/MEDLINE; all full text papers published in from January 1966 to November 2009 on the use of NSAIDs in acute pancreatitis were collected; the literature search was also supplemented by a review of the bibliographies of the papers evaluated. Thus, in this article, we will systematically review the current literature in order to better illustrate the role of NSAIDs in acute pancreatitis, in particular: i) NSAIDs as a cause of acute pancreatitis; ii) their use to prevent post-retrograde ERCP pancreatitis and iii) their efficacy for pain relief in the acute illness of the pancreas.

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Section: Literature Searchmentioning

confidence: 99%

NSAIDs and Acute Pancreatitis: A Systematic Review

2010

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“…However, there is one case report on a 5-ASA-induced acute pancreatitis after the use of 5-ASA suppositories [30]. In addition, one case report has been published of a 5-ASA enema-induced relapse of acute pancreatitis in a patient who had already had a 5-ASA-induced acute pancreatitis after intake of oral 5-ASA [31]. This highlights that re-exposure to topical 5-ASA in the case of pancreatitis, myocarditis, epicarditis or interstitial nephritis and other forms of 5-ASA hypersensitivity reactions requires a very careful risk/benefit analysis.…”

Section: Side Effects Of Topical Therapymentioning

confidence: 99%

Topical Therapies in Inflammatory Bowel Disease

et al. 2012

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Due to misunderstandings about their effectiveness and feasibility, topical (or rectal) therapies with aminosalicylates (5-aminosalicylic acid, 5-ASA) and steroids are often underused in patients with ulcerative colitis (UC). However, many of these patients could be treated solely with rectal/topical therapies, or could benefit from them in combination with oral therapies. We review the evidence for topical therapies containing 5-ASA and budesonide in UC and discuss how these therapies can be optimized in daily practice, thereby improving compliance. Finally, we provide a brief summary of studies on the use of other topical treatments in UC, the results of which were both promising and negative.

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“…Pancreatides caused by pharmaceuticals also come into consideration as the cause of a lipase/amylase increase, in addition to the possible participation of the pancreas as an extra-intestinal manifestation of chronic inflammatory intestinal disease. Druginduced pancreatides (e. g. after intake of azathioprine or 5-ASA) have been repeatedly-described [8,13,23,30].…”

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confidence: 99%