Akut İskemik İnme İçin Mekanik Trombektomi Sonrası Klinik Sonuçlarla Tam Kan Viskozitesinin İlişkisi

Abstract

Background: Blood viscosity (BV) is relationship cerebrovascular events. However, the association with between BV and clinical outcomes after acute ischemic stroke (AIS) has not been studied. This study evaluated the relationship between whole blood viscosity (WBV) and clinical outcomes after AIS. Materials and Methods: The study enrolled 240 consecutive patients with AIS who underwent mechanical thrombectomy (MT) between 2017 and 2019 years. The all patients were divided according to the modified Rankin Scale (mRS) score, as good (mRS 0-2) and poor (mRS 3-6) clinical outcomes group. WBV was calculated by the formula derived from total protein and haematocrit levels. Results: Poor clinical outcomes group presented significantly higher WBV values both at LSR and HSR (p < 0.001). Multivariate analysis, both high WBV at LSR (Odd ratio: 2.679, p < 0.001) and high WBV at HSR (Odd ratio: 1.278, p < 0.001) were independent predictors for poor clinical outcomes. In receiver operating characteristic analysis, value of 16.1 WBV at HSR had 76.7% sensitivity and 76% specificity for predicting poor clinical outcomes and a value of 38.5 WBV at LSR had 75.3% sensitivity and 78% specificity for predicting poor clinical outcomes. There was a significant positive correlation between WBV at LSR and mRS score (0-6) (r = 0.457, p <0.001) and WBV at HSR and mRS score (0-6) (r = 0.452, p <0.001). Conclusions: Increased WBC may be independent risk factor and correlated with poor clinical outcomes in AIS patients treated with MT.