Aktuelles zur Syphilistherapie und zur serologischen Kontrolle

Heise, H

doi:10.1007/s00105-004-0834-0

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…A fourfold or greater decrease of the antibody titer after 6 months correlates with decreased antibody levels and a high probability of successful therapy of primary and secondary syphilis [7, 47]. The longer syphilis has existed, the slower normalization of the reactions occurs [45, 48]. In later latency this can be expected after one year [48].…”

Section: Problems In Laboratory Diagnosis Of Syphilismentioning

confidence: 99%

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Diagnosis of syphilis: Clinical and laboratory problems

Lautenschlager

2006

J Deutsche Derma Gesell

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Section: Problems In Laboratory Diagnosis Of Syphilismentioning

confidence: 99%

“…The longer syphilis has existed, the slower normalization of the reactions occurs [45, 48]. In later latency this can be expected after one year [48]. In less than 5% of patients the reactions do not revert despite adequate therapy, a condition termed “sero‐fast”.…”

Section: Problems In Laboratory Diagnosis Of Syphilismentioning

confidence: 99%

Diagnosis of syphilis: Clinical and laboratory problems

Lautenschlager

2006

J Deutsche Derma Gesell

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“…[17,18,24] The clemizole-penicillin combination was widely employed for treating syphilis. [25][26][27] Nowadays, clemizole becomes popular again with not only its antihistaminic features but also the blocking effects of TRPC5 cation channels, specifically. On the other hand, Cis is widely used in the treatment of several malignancies as an antitumoral drug.…”

Section: Discussionmentioning

confidence: 99%

Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin‐induced nephrotoxicity in Spraque–Dawley rats

Kumaş

Gepdíremen

Karataş

et al. 2023

J Biochem & Molecular Tox

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Cis‐diamminedichloroplatinum (II) (cisplatin, Cis) is widely employed to treat several types of cancer. It has many important toxic side effects; one of the most important of which is nephrotoxicity. Clemizole hydrochloride (Clem) as the most potent inhibitor of TRPC5 channels was tested in an animal model of Cis‐induced nephrotoxicity. Rats were divided into the following groups: control; Cis (8 mg/kg); Cis + 1 mg/kg Clem; Cis + 5 mg/kg Clem; Cis + 10 mg/kg Clem. Kidney injury was detected by histopathological and biochemical analysis. Urine urea nitrogen (UUN), creatinine, urine neutrophil gelatinase‐associated lipocalin (NGAL), serum catalase (CAT), and malondialdehyde (MDA) levels were determined by enzyme‐linked immunosorbent assay. Total antioxidant status (TAS) and total oxidant status (TOS) were studied using a colorimetric assay. Nephrin, synaptopodin, and Rac family small GTPase 1 (RAC1) expressions were detected by Western blot analysis. Cis was found to induce histopathological alterations, including tubular degeneration, congestion, hemorrhage, hyaline casts, glomerular collapse, and apoptotic cell death. Clem at a dose of 1 and 5 mg/kg attenuated histopathological alterations. UUN, creatinine, and NGAL levels increased in the Cis‐administered group, while all doses of Clem decreased in those. CAT and TAS levels decreased, while TOS and oxidative stress index levels increased in the Cis‐treated group. A dose of 1 and 5 mg Clem showed antioxidant effects against oxidative stress. Cis induced lipid peroxidation by increasing MDA levels. All doses of Clem reduced MDA levels. Nephrin and synaptopodin expressions were decreased by Cis, and all doses of Clem increased that. All doses of Clem successfully depressed RAC1 expression. Clem showed a highly ameliorating effect on toxicity caused by Cis by blocking TRPC5 calcium channels.

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Aktuelles zur Syphilistherapie und zur serologischen Kontrolle

Cited by 2 publications

References 6 publications

Diagnosis of syphilis: Clinical and laboratory problems

Diagnosis of syphilis: Clinical and laboratory problems

Clemizole hydrochloride, a potent TRPC5 calcium channel inhibitor, prevents cisplatin‐induced nephrotoxicity in Spraque–Dawley rats

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