Aktivitätsbestimmung von Phosphor-32 mit Hilfe der <i>Tscherenkow</i>-Strahlung

Rowińska, L.; Jaskólska, H.; Radwan, M.

doi:10.1080/10256017508543780

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…If the charged particles in the polarizable medium travel slower than the respective speed of light within the same medium, the resulting radiation waves cancel each other. Therefore, the threshold condition for the induction of CR depends on the refractive index of the polarizable medium as well as on the energy level of the charged particles [30]. The velocity in the respective medium v can be calculated using the following equation, where n is the refractive index of the medium and c is the speed of light in vacuum.…”

Section: Introductionmentioning

confidence: 99%

Photopharmacological Applications for Cherenkov Radiation Generated by Clinically Used Radionuclides

Krebs

Döbber

Rodat

et al. 2021

IJMS

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Translational photopharmacological applications are limited through irradiation by light showing wavelengths within the bio-optical window. To achieve sufficient tissue penetration, using wavelengths >500 nm is mandatory. Nevertheless, the majority of photopharmacological compounds respond to irradiation with more energetic UV light, which shows only a minor depth of tissue penetration in the µm range. Thus, we became interested in UV light containing Cherenkov radiation (CR) induced as a by-product by clinically employed radionuclides labeling specific tissues. Therefore, CR may be applicable in novel photopharmacological approaches. To provide evidence for the hypothesis, we verified the clinically established radionuclides 68Ga and 90Y but not 18F in clinically used activities to be capable of generating CR in aqueous solutions. We then investigated whether the generated CR was able to photoactivate the caged kinase inhibitor cagedAZD5438 as a photoresponsive model system. Herein, 21% uncaging of the model system cagedAZD5438 occurred by incubation with 90Y, along with a non-specific compound decomposition for 68Ga and partly for 90Y. The findings suggest that the combination of a clinically employed radionuclide with an optimized photoresponsive agent could be beneficial for highly focused photopharmacological therapies.

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Section: Introductionmentioning

confidence: 99%