Aktionsströme des Zentralnervensystems unter der Einwirkung von Krampfgiften

Fischer, M. H.; Löwenbach, H.

doi:10.1007/bf01864468

Cited by 22 publications

(9 citation statements)

References 6 publications

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“…The investigation of DB is rooted in research of epilepsy and thus strongly associated with pathophysiological activity (Fischer & Löwenbach, ; Goldensohn & Purpura, ). Depolarization block and the involvement of TRPC channels in epilepsy was extensively studied in vivo using the pilocarpine model in mice (Phelan et al, , , ; Zheng, ; Zheng & Phelan, ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, PF was discovered in a wealth of different brain areas (Dembrow et al, ; Egorov et al, ; McQuiston & Madison, ; Rahman & Berger, ; Yan et al, ) and cell types (Egorov et al, ; McQuiston & Madison, ; Sheffield, Best, Mensh, Kath, & Spruston, ; Suzuki, Tang, & Bekkers, ), including CA1 pyramidal neurons (Knauer et al, ). Accounting for inconsistent nomenclature (DB can be part of a paroxysmal depolarizing shift), the investigation of DB has a longer history with first epileptiform discharges being recorded in the 1930s (Fischer & Löwenbach, ) and the first intracellular recording of DB being published in the 1960s (Goldensohn & Purpura, ). Thus far, PF (Knauer et al, ) and DB (Fraser et al, ;Fraser & MacVicar, ; Tai et al, ) in CA1 pyramidal neurons were investigated independently.…”

Section: Discussionmentioning

confidence: 99%

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Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons

Knauer

Yoshida

2019

Hippocampus

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The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during cholinergic stimulation. However, it is unknown whether these cells constitute disparate populations of neurons. Furthermore, it is unclear which cell‐specific peculiarities may mediate their diverse response properties. However, it has not been shown whether individual CA1 pyramidal neurons can switch between PF and DB states. Here, we used whole cell patch clamp in the current clamp mode on in vitro CA1 pyramidal neurons from acutely sliced rat tissue to test various intrinsic properties which may provoke individual cells to switch between PF and DB. We found that individual cells could switch from PF to DB, in a cholinergic agonist concentration dependent manner and depending on the parameters of stimulation. We also demonstrate involvement of TRPC and potassium channels in this switching. Finally, we report that the probability for DB was more pronounced in the proximal than in the distal half of CA1. These findings offer a potential mechanism for the stronger spatial modulation in proximal, compared to distal CA1, as place field formation was shown to be affected by DB. Taken together, our results suggest that PF and DB are not mutually exclusive response properties of individual neurons. Rather, a cell's response mode depends on a variety of intrinsic properties, and modulation of these properties enables switching between PF and DB.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons

Knauer

Yoshida

2019

Hippocampus

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“…Berger’s publications, in a dense academic German (Gloor, 1969), were not widely credited until the corroborating studies of Adrian & Matthews, 1934. Progress was, however, rapid: Fischer and Lowenbach (1934) published the first demonstration of epileptiform spikes, and a year later Gibbs and Davis (1935) reported the classic pattern of absence seizures, in fact a rediscovery of some of Berger’s work. In 1936, the first EEG laboratory opened at the Massachusetts General Hospital as a research facility.…”

Section: Clinical Neurophysiology and The Human Eegmentioning

confidence: 99%

Clinical neurophysiology with special reference to the electroencephalogram

Avanzini¹

2009

Epilepsia

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Summary In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram (EEG) by Hans Berger, a German psychiatrist. Originally received with skepticism, the EEG became a subject of intense interest, and after World War II, became a leading clinical and experimental tool in neurology. Today, it remains important especially in the study and treatment of epilepsy. Though the EEG has also given rise to more sophisticated applications, these remain based on Berger’s initial work, one of the great discoveries of medical history.

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“…The importance of multichannel recordings and using a large number of electrodes to cover a wider brain region was recognized by Kornm üller [10]. The first EEG work focusing on epileptic manifestation and the first demonstration of epileptic spikes were presented by Fischer and Löwenbach [11][12][13].…”

Section: O P Y R I G H T E D M a T E R I A Lmentioning

confidence: 99%

Introduction to EEG

Sanei

Chambers²

2007

EEG Signal Processing

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The neural activity of the human brain starts between the 17th and 23rd week of prenatal development. It is believed that from this early stage and throughout life electrical signals generated by the brain represent not only the brain function but also the status of the whole body. This assumption provides the motivation to apply advanced digital signal processing methods to the electroencephalogram (EEG) signals measured from the brain of a human subject, and thereby underpins the later chapters of the book.Although nowhere in this book do the authors attempt to comment on the physiological aspects of brain activities there are several issues related to the nature of the original sources, their actual patterns, and the characteristics of the medium, that have to be addressed. The medium defines the path from the neurons, as so-called signal sources, to the electrodes, which are the sensors where some form of mixtures of the sources are measured.Understanding of neuronal functions and neurophysiological properties of the brain together with the mechanisms underlying the generation of signals and their recordings is, however, vital for those who deal with these signals for detection, diagnosis, and treatment of brain disorders and the related diseases. A brief history of EEG measurements is first provided.

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Aktionsströme des Zentralnervensystems unter der Einwirkung von Krampfgiften

Cited by 22 publications

References 6 publications

Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons

Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons

Clinical neurophysiology with special reference to the electroencephalogram

Introduction to EEG

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