Akkermansia muciniphila Suppresses High-Fat Diet-Induced Obesity and Related Metabolic Disorders in Beagles

Lin, Xiaoqi; Chen, Wei; Ma, Ke; Liu, Zhenzhen; Gao, Yu; Zhang, Jiangang; Wang, Tao; Yang, Yongjun

doi:10.3390/molecules27186074

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…Also commensal bacteria such as Faecalibacterium prausnitzii were shown to effectively promote gut diversity and SCFA production and by this mechanism, shows great potential in improving inflammatory and metabolic diseases ( 88 – 92 ). As previously mentioned, A. muciniphila administration can improve metabolic anomalies caused by gut dysbiosis ( 53 , 54 , 93 ). Thus single-strain-based probiotics seem to be able to competently promote gut homeostasis.…”

Section: Scfa Production In the Gutmentioning

confidence: 81%

The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

Kopczyńska,

Kowalczyk

2024

Front. Immunol.

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Obesity and chronic low-grade inflammation, often occurring together, significantly contribute to severe metabolic and inflammatory conditions like type 2 diabetes (T2D), cardiovascular disease (CVD), and cancer. A key player is elevated levels of gut dysbiosis-associated lipopolysaccharide (LPS), which disrupts metabolic and immune signaling leading to metabolic endotoxemia, while short-chain fatty acids (SCFAs) beneficially regulate these processes during homeostasis. SCFAs not only safeguard the gut barrier but also exert metabolic and immunomodulatory effects via G protein-coupled receptor binding and epigenetic regulation. SCFAs are emerging as potential agents to counteract dysbiosis-induced epigenetic changes, specifically targeting metabolic and inflammatory genes through DNA methylation, histone acetylation, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). To assess whether SCFAs can effectively interrupt the detrimental cascade of obesity and inflammation, this review aims to provide a comprehensive overview of the current evidence for their clinical application. The review emphasizes factors influencing SCFA production, the intricate connections between metabolism, the immune system, and the gut microbiome, and the epigenetic mechanisms regulated by SCFAs that impact metabolism and the immune system.

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Section: Scfa Production In the Gutmentioning

confidence: 81%

The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

Kopczyńska,

Kowalczyk

2024

Front. Immunol.

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“…Ruminococcaceae and Rikenellaceae families were elevated in high-fat diet-fed mice, and specific alterations in IM composition induced by the high-fat diet contribute to the obese phenotype [ 102 , 104 ]. Akkermansia muciniphila populations, notably reduced in congenitally obese and high-fat-diet-induced obese mice, play a role in weight gain and IM composition [ 105 ]. This bacterial species, colonizing the mucus layer due to its mucus-degrading ability, was found to be negatively correlated with body weight, Type 1 diabetes, and Type 2 diabetes.…”

Section: Metabolome’s Pathogenic Biomolecular Mechanics In Metsmentioning

confidence: 99%

Biomolecular Actions by Intestinal Endotoxemia in Metabolic Syndrome

Charitos,

Aliani,

Tondo

et al. 2024

IJMS

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Metabolic syndrome (MetS) is a combination of metabolic disorders that concurrently act as factors promoting systemic pathologies such as atherosclerosis or diabetes mellitus. It is now believed to encompass six main interacting conditions: visceral fat, imbalance of lipids (dyslipidemia), hypertension, insulin resistance (with or without impairing both glucose tolerance and fasting blood sugar), and inflammation. In the last 10 years, there has been a progressive interest through scientific research investigations conducted in the field of metabolomics, confirming a trend to evaluate the role of the metabolome, particularly the intestinal one. The intestinal microbiota (IM) is crucial due to the diversity of microorganisms and their abundance. Consequently, IM dysbiosis and its derivate toxic metabolites have been correlated with MetS. By intervening in these two factors (dysbiosis and consequently the metabolome), we can potentially prevent or slow down the clinical effects of the MetS process. This, in turn, may mitigate dysregulations of intestinal microbiota axes, such as the lung axis, thereby potentially alleviating the negative impact on respiratory pathology, such as the chronic obstructive pulmonary disease. However, the biomolecular mechanisms through which the IM influences the host’s metabolism via a dysbiosis metabolome in both normal and pathological conditions are still unclear. In this study, we seek to provide a description of the knowledge to date of the IM and its metabolome and the factors that influence it. Furthermore, we analyze the interactions between the functions of the IM and the pathophysiology of major metabolic diseases via local and systemic metabolome’s relate endotoxemia.

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The diarrheal mechanism of mice with a high-fat diet in a fatigued state is associated with intestinal mucosa microbiota

et al. 2023

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Akkermansia muciniphila Suppresses High-Fat Diet-Induced Obesity and Related Metabolic Disorders in Beagles

Cited by 8 publications

References 45 publications

The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesity

Biomolecular Actions by Intestinal Endotoxemia in Metabolic Syndrome

The diarrheal mechanism of mice with a high-fat diet in a fatigued state is associated with intestinal mucosa microbiota

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