Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer
Yao Yu,
Leqian Li,
Qishen Yang
et al.
Abstract:Prostate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses to castration-resistant prostate cancer (CRPC) with a poor prognosis. This study indicated that some PCa patients and mice were more sensitive to ADT and entered CRPC later, which was related to the gut microbiota, especially the enrichment of Akkermansia muciniphila (AKK). Untargeted metabolomics analysis found that serum inosine level was upregulated in the treatment-sensitive … Show more
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