Akkermansia muciniphila is Negatively Correlated with Hemoglobin A1c in Refractory Diabetes

Shih, Ching‐Tang; Yeh, Yao‐Tsung; Lin, Ching‐Chiang; Yang, Linyu; Chiang, Chiao-Ching

doi:10.3390/microorganisms8091360

Cited by 34 publications

(29 citation statements)

References 63 publications

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“… 35 In addition, in previous studies on refractory diabetes and autism spectrum disorders, it was known that the abundances of B. vulgatus and A. muciniphila are inversely proportional. 36 37 This inverse relationship between these two species was also confirmed in the present study, suggesting that the relationship between the two species provides insights on the pathophysiology of EEN.…”

Section: Discussionsupporting

confidence: 88%

The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model

et al. 2021

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Background Exclusive enteral nutrition (EEN) induces remission in pediatric Crohn's disease (CD). The exact mechanism of EEN therapy in CD is unknown, but alteration of the intestinal microflora after EEN is thought to affect mucosal healing. To determine the link between EEN therapy and therapeutic efficacy in CD, we established a murine model of dextran sulfate sodium (DSS)-induced colitis and applied EEN therapy. Methods Eight-week-old C57BL/6 mice were administered DSS for 4 days to induce colitis, and either normal chow (NC) or EEN was administered for the following 4 days. The mice were grouped according to the feeding pattern after DSS administration: DSS/NC and DSS/EEN groups. The clinical course was confirmed via daily observation of the weight and stool. Fecal samples were collected and 16sRNA sequencing was used. The mice were sacrificed to confirm colonic histopathology. Results Weight reduction and increase in disease activity were observed as the day progressed for 4 days after DSS administration. There was significant weight recovery and improvement in disease activity in the EEN group compared to that in the NC group. Verrucomicrobia and Proteobacteria abundances tended to increase and Bacteroidetes abundance decreased in the EEN group. In the EEN group, significant changes in the β-diversity of the microbiota were observed. In the analysis of microbiome species, abundances of Akkermansia muciniphila , Clostridium cocleatum , mucin-degrading bacteria, Flintibacter butyricus , and Parabacteroides goldsteinii , which are beneficial microbiota, were significantly increased in the EEN group compared to those in the NC group. More abundant mucins were confirmed in the colonic histopathology of the EEN group. These microbial and histopathological differences suggested that EEN might improve colitis symptoms in a murine colitis model by promoting mucin recycling and subsequently inducing the healing effect of the gut barrier. Conclusion EEN showed clinical efficacy in a murine model of colitis. Based on the increase in mucin-degrading bacteria and the pathological increase in mucin production after EEN administration, it can be observed that mucin plays an important role in the therapeutic effect of EEN.

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Section: Discussionsupporting

confidence: 88%

The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model

et al. 2021

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“…Raw paired-end reads were also analyzed using the BaseSpace Ribosomal Database Project (RDP) classifier. OTUs (relative abundance), α-diversity (Shannon entropy and Venn diagram), and β-diversity (PCoA-D_0.5 UniFrac) were determined using BaseSpace (Illumina, San Diego, CA, USA), CLC Genomics Workbench 21 with Microbial Genomics Module (Qiagen, Germantown, MD, USA) and GraphPad Prism 8 (GraphPad Software, La Jolla, CA, USA) 19 .…”

Section: Methodsmentioning

confidence: 99%

“…Correlations were calculated using the Pearson correlation coefficient. All statistical analyses were performed using GraphPad Prism 8 (GraphPad Software, La Jolla, CA, USA) 19 .…”

Section: Methodsmentioning

confidence: 99%

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Hou

Ou‐Yang

et al. 2021

Exp Mol Med

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In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.

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“…Evidence also suggests that Akkermansia prefers to ingest carbohydrates (mainly polysaccharides) as its nutritional source [34]. A. muciniphila has the ability to improve diabetes, reducing body fat production, and suppressing weight gain; therefore, increasing A. muciniphila in the intestines through diet is believed to have the ability to improve metabolic syndrome [49,50]. As shown in Figure 10A, the relative abundances of Akkermansia spp.…”

Section: The Regulation Of C Militaris On Gut Microbiota In Hfsd-induced Micementioning

confidence: 99%

Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet

Lee

Chen

Hsu

et al. 2021

Foods

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Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota. In this study, the effects of C. militaris and its fractions on modifying metabolic syndrome in mice were evaluated. Mice were fed a high-fat/high-sucrose diet (HFSD) for 14 weeks to induce body weight increase and hyperlipidemia symptoms in mice, and then the mice were simultaneously given a HFSD and C. militaris samples for a further 8 weeks. The results indicated that the fruit body, polysaccharides, and cordycepin obtained from C. militaris had different efficacies on regulating metabolic syndrome and gut microbiota in HFSD-treated mice. Polysaccharides derived from C. militaris decreased the levels of blood sugar and serum lipids in mice fed HFSD. In addition, C. militaris-polysaccharide treatment obviously improved intestinal dysbiosis through promoting the population of next generation probiotic Akkermansia muciniphila in the gut of mice fed HFSD. In conclusion, polysaccharides derived from C. militaris have the potential to act as dietary supplements and health food products for modifying the gut microbiota to improve the metabolic syndrome.

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Akkermansia muciniphila is Negatively Correlated with Hemoglobin A1c in Refractory Diabetes

Cited by 34 publications

References 63 publications

The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model

The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet

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