AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression

Wan, Sicheng; Liu, Chaolong; Li, Chongyang; Wang, Zhi; Zhao, Gaichao; Li, Jingui; Ran, Wenhao; Zhong, Xi; Li, Yongsen; Zhang, Li; Cui, Hongjuan

doi:10.1038/s41388-023-02796-2

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…To detect cell proliferation ability, 1 × 10 3 stable transfected MKN45 and HGC27 cells were cultured in 96 well plates and 6 well plates for 6 and 15 days, respectively. As mentioned previously [35], cell viability was detected by cell counting and MTT assay. After staining with crystal violet, the scanning plate clone formation assay was used, and the absorption rate of 560 was nally measured using absolute ethanol to measure nm for statistical analysis.…”

Section: Cell Proliferation Detection and Plate Colony Formation Expe...mentioning

confidence: 99%

TRIP13 regulates progression of gastric cancer through mediating ubiquitination modification of DDX21

Zhang,

Yang,

Wang

et al. 2024

Preprint

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GC (Gastric cancer) is one of the most common malignant tumors, with over 95% of gastric cancer patients being adenocarcinoma and most gastric cancer patients having no obvious symptoms in the early stages. Therefore, finding biomarkers for early screening of gastric cancer and exploring new targets for gastric cancer treatment are urgent problems to be solved in the treatment of gastric cancer, it has important clinical significance in improving the survival rate of gastric cancer patients. The AAA + family ATPase thyroid hormone receptor interacting protein 13 (TRIP13) has been reported to play an important role in the development of various tumors, however, the biological function and mechanism of TRIP13 in gastric cancer are remain unclear. Here, our study confirms that TRIP13 is highly expressed in gastric cancer tissue samples, and that TRIP13 participates in the proliferation, migration, and invasion of gastric cancer cells. Mechanistically, our study confirms that TRIP13 directly interacts with DDX21 and stabilizes its expression by restraining its ubiquitination degradation, thereby promoting the progression of gastric cancer. Additionally, we found that histone deacetylase 1 (HDAC1) is an upstream factor of TRIP13, which could target the TRIP13 promoter region to promote the proliferation, migration, and invasion of gastric cancer cells. These results indicate that TRIP13 serve as a promising biomarker for the treatment of gastric cancer patients, and the HDAC1-TRIP13/DDX21 axis might provide solid theoretical basis for clinical treatment of gastric cancer patients.

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Section: Cell Proliferation Detection and Plate Colony Formation Expe...mentioning

confidence: 99%

TRIP13 regulates progression of gastric cancer through mediating ubiquitination modification of DDX21

Zhang,

Yang,

Wang

et al. 2024

Preprint

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show abstract

“…AKIP1 is responsible for interacting with protein kinase A (PKA), an enzyme that plays a key role in cellular signaling pathways promoting tumor progression. Therefore, inhibiting AKIP1 was found to have anti-tumor effects via the inhibition of its interaction with PKA [ 22 ]. Furthermore, through its interaction with YY1-mediated Heat Shock Protein 90 Alpha Family Class A Member 1 (HSP90AA1), it stabilizes EGFR.…”

Section: Expression and Activity Of Yy1 In Gbmmentioning

confidence: 99%

“…Furthermore, through its interaction with YY1-mediated Heat Shock Protein 90 Alpha Family Class A Member 1 (HSP90AA1), it stabilizes EGFR. However, HSP90α overexpression reverses EGFR instability caused by AKIP1 depletion, highlighting AKIP1’s significance in GBM progression and revealing a new EGFR regulatory mechanism [ 22 ]. In another study investigating the role of guanylate binding protein 1 (GBP1), it was found that EGFR activation induces GBP1 expression in GBM cell lines through a signaling pathway involving Src and p38 mitogen-activated protein kinase [ 23 ].…”

Section: Expression and Activity Of Yy1 In Gbmmentioning

confidence: 99%

Therapeutic Implications of Targeting YY1 in Glioblastoma

Navasardyan,

Zaravinos,

Bonavida

2024

Cancers

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The transcription factor Yin Yang 1 (YY1) plays a pivotal role in the pathogenesis of glioblastoma multiforme (GBM), an aggressive form of brain tumor. This review systematically explores the diverse roles of YY1 overexpression and activities in GBM, including its impact on the tumor microenvironment (TME) and immune evasion mechanisms. Due to the poor response of GBM to current therapies, various findings of YY1-associated pathways in the literature provide valuable insights into novel potential targeted therapeutic strategies. Moreover, YY1 acts as a significant regulator of immune checkpoint molecules and, thus, is a candidate therapeutic target in combination with immune checkpoint inhibitors. Different therapeutic implications targeting YY1 in GBM and its inherent associated challenges encompass the use of nanoparticles, YY1 inhibitors, targeted gene therapy, and exosome-based delivery systems. Despite the inherent complexities of such methods, the successful targeting of YY1 emerges as a promising avenue for reshaping GBM treatment strategies, presenting opportunities for innovative therapeutic approaches and enhanced patient outcomes.

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TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21

Zhang,

Yang,

Wang

et al. 2024

Cell Death Dis

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GC (Gastric cancer) is one of the most common malignant tumours, with over 95% of gastric cancer patients being adenocarcinoma and most gastric cancer patients having no apparent symptoms in the early stages. Finding biomarkers for early screening of gastric cancer and exploring new targets for gastric cancer treatment are urgent problems to be solved in the treatment of gastric cancer, with significant clinical outcomes for the survival rate of gastric cancer patients. The AAA+ family ATPase thyroid hormone receptor-interacting protein 13 (TRIP13) has been reported to play an essential role in developing various tumours. However, the biological function and molecular mechanism of TRIP13 in gastric cancer remain unclear. This study confirms that TRIP13 is highly expressed in gastric cancer tissue samples and that TRIP13 participates in the proliferation, migration, invasion in vitro, and tumourigenesis and metastasis in vivo of gastric cancer cells. Mechanistically, this study confirms that TRIP13 directly interacts with DDX21 and stabilises its expression by restraining its ubiquitination degradation, thereby promoting gastric cancer progression. Additionally, histone deacetylase 1 (HDAC1) is an upstream factor of TRIP13, which could target the TRIP13 promoter region to promote the proliferation, migration, and invasion of gastric cancer cells. These results indicate that TRIP13 serve is a promising biomarker for the treating of gastric cancer patients, and the HDAC1-TRIP13/DDX21 axis might provide a solid theoretical basis for clinical treatment of gastric cancer patients.

show abstract

AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression

Cited by 4 publications

References 60 publications

TRIP13 regulates progression of gastric cancer through mediating ubiquitination modification of DDX21

TRIP13 regulates progression of gastric cancer through mediating ubiquitination modification of DDX21

Therapeutic Implications of Targeting YY1 in Glioblastoma

TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21

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