Akinetic mutism in Wernicke-Korsakoff disease: a case report.

Mann, Manish; Degos, Jean‐Denis

doi:10.1136/jnnp.51.4.588

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…It is associated with abnormality in the anterior or mesial frontal lobes or in the diencephalic-mesencephalic region affecting limbic circuitry. Some causes of akinetic mutism are frontal lobe or thalamic infarcts, 2 obstructive hydrocephalus, 3 Wernicke' s encephalopathy, 4 and postradiation leukoencephalopathy. 5…”

Section: (Pharmacotherapy 1999;19(4):468-470)mentioning

confidence: 99%

Reversible Akinetic Mutism Possibly Induced by Baclofen

Rubin

1999

Pharmacotherapy

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A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-induced akinetic mutism in a patient with normal renal function. The pathophysiology of this condition is unknown, but it may result from selective binding of the drug to the gamma-aminobutyric acid-B receptors located in the frontal lobes or thalamic nuclei, interrupting the thalamocortical limbic pathways.

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Section: (Pharmacotherapy 1999;19(4):468-470)mentioning

confidence: 99%

Reversible Akinetic Mutism Possibly Induced by Baclofen

Rubin

1999

Pharmacotherapy

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Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis

Psarros¹,

Zouros²,

Coimbra³

2003

Journal of Neurosurgery

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A 26-year-old woman with obstructive hydrocephalus caused by a cysticercal cyst blocking the left foramen of Monro was initially treated with an external ventriculostomy and subsequent endoscopically assisted cyst resection and septostomy. Postoperatively, the patient developed the clinical syndrome of akinetic mutism, but her condition improved after the administration of the dopaminergic agonist bromocriptine. This result indicates that a disruption in the ascending dopaminergic pathway involved in behavior formation was likely the cause of these neurological symptoms.

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Akinetic mutism in Wernicke-Korsakoff disease: a case report.

Cited by 2 publications

References 3 publications

Reversible Akinetic Mutism Possibly Induced by Baclofen

Reversible Akinetic Mutism Possibly Induced by Baclofen

Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis

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