Akinesia due to catecholamine depletion in mice is prevented by caffeine. Further evidence for an involvement of adenosinergic system in the control of motility

Popoli, Patrizia; Caporali, Maurizio; Carolis, A. Scotti de

doi:10.1111/j.2042-7158.1991.tb06685.x

Cited by 22 publications

(13 citation statements)

References 8 publications

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“…This has been repeatedly demonstrated in a number of experimental models involving rodents pretreated with D 2 receptor antagonists, reserpine, or MPTP or after genetic inactivation of D 2 receptors Popoli et al, 1991;Kanda et al, 1994;Giménez-Llort et al, 1995;Pollack and Fink, 1995;Malec, 1997;Shiozaki et al, 1999;Ward and Dorsa, 1999;Wardas et al, 1999;Aoyama et al, 2000;Chen et al, 2001;Ferré et al, 2001;Hauber et al, 2001) and involving MPTP-treated monkeys (Kanda et al, 1998a,b;Grondin et al, 1999). The results of these experiments suggest that A 2A receptor antagonists can be useful in the treatment of Parkinson's disease.…”

Section: Interactions Between Adenosinementioning

confidence: 60%

“…• The drug is developed for one coreceptor to modulate another coreceptor at the recognition level (binding pocket (Fuxe and Ungerstedt, 1974;Fredholm et al, 1983;Herrera-Marschitz et al, 1988;Casas et al, 1988;Popoli et al, 1991Jiang et al, 1993Kanda et al, 1994) and recent work (Malec, 1997;Kanda et al, 1998a,b;Grondin et al, 1999;Shiozaki et al, 1999;Ward and Dorsa, 1999;Wardas et al, 1999;Aoyama et al, 2000;Strömberg et al, 2000;Chen et al, 2001;Ferré et al, 2001;Fuxe et al, 2001;Hauber et al, 2001;Pinna et al, 2001;Morelli and Wardas, 2001; T. Chase, personal communication).…”

Section: Possible Targets For Drugs Acting On Heteromeric Receptormentioning

confidence: 99%

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Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

et al. 2003

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Section: Interactions Between Adenosinementioning

confidence: 60%

Section: Possible Targets For Drugs Acting On Heteromeric Receptormentioning

confidence: 99%

Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

et al. 2003

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“…Three other studies reported less coffee consumption among PD cases than controls [18,25,26], although this was significant in only one [26]. Both ethanol [27,28] and caffeine [29][30][31] affect dopamine transmission and turnover in the basal ganglia and other brain regions.…”

Section: Discussionmentioning

confidence: 96%

Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study

2001

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We conducted a case-control study nested within a prospective cohort study of 13,979 residents of Leisure World Laguna Hills, a retirement community in southern California, for etiologic clues for Parkinson’s disease (PD). Between 1981 (when first mailed a health survey) and 1998, we identified 395 PD cases from death certificates, hospital discharge diagnoses and a 1992 follow-up questionnaire. Six controls were individually matched on sex, birth date (±2 years), vital status and, if dead, death date (±1 year) to each case. Baseline characteristics of the 395 cases and 2,320 controls were analyzed as potential PD risk factors. The risk of PD was significantly reduced among smokers, hypertensives, coffee drinkers and alcohol consumers, and significantly increased among those with 3 or more children and with a high intake of total vitamin A and dietary vitamin C. The multivariate odds ratios (95% confidence intervals) were 0.42 (0.22–0.80) for current cigarette smokers of 1+ pack/day, 0.62 (0.48–0.80) for current users of hypertensive medication, 0.71 (0.52–0.95) for coffee drinkers of 2+ cups/day and 0.77 (0.58–1.03) for drinkers of 2+ alcoholic drinks/day. Risk increased with increasing number of children (1.25 for 1, 1.34 for 2 and 1.90 for 3+ children; p for trend = 0.0003). The increased risks among individuals in the highest third of total vitamin A intake and of dietary vitamin C intake were no longer statistically significant after adjusting for the other variables. These findings suggest several environmental factors that may be related to the development of PD and support a multifactorial etiology.

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“…Finally, different biological and experimental evidence suggests a real role of coffee and caffeine consumption in reducing the risk of PD [40][41][42]. Animal models in particular indicate that caffeine may act not just by preventing PD but simply by delaying the onset of disease symptoms [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study on Cigarette, Alcohol, and Coffee Consumption Preceding Parkinson’s Disease

Ragonese¹,

Salemi²,

Morgante

et al. 2003

Neuroepidemiology

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Objective: To investigate the association between cigarette smoking, alcohol drinking, coffee consumption and Parkinson’s disease (PD). Methods: We selected subjects affected by idiopathic PD, with a Mini-Mental State Examination of ≧24, and controls matched 1 to 1 with cases by age (± 2 years) and sex. Controls were randomly selected from the resident list of the same municipality of residence of the cases. We assessed cigarette smoking, alcohol drinking, and coffee consumption preceding the onset of PD or the corresponding time for controls using a structured questionnaire, which also evaluated the duration and dose of exposure. Using conditional logistic regression analysis, we calculated adjusted OR and 95% CI. Results: We interviewed 150 PD patients and 150 matched controls. Cigarette smoking (ever vs. never smokers OR = 0.66, 95% CI = 0.41–1.05, p = 0.08) did not show a statistically significant association with PD. We observed an inverse association between alcohol drinking (ever vs. never OR = 0.61, 95% CI = 0.39–0.97, p = 0.037) and coffee consumption (ever vs. never OR = 0.16, 95% CI 0.05–0.46, p = 0.0001) and PD. These associations remained significant after adjustment for other covariates: OR for ever vs. never alcohol consumption was 0.62 (95% CI = 0.43–0.89, p = 0.009) and that for coffee drinking 0.19 (95% CI = 0.07–0.52, p = 0.001). Heavy coffee consumption confirmed the inverse association between coffee and PD (more than 81 cup/year vs. none: OR = 0.20, 95% CI = 0.08–0.47, p ≤ 0.0001). Conclusions: Consistent with previous studies, our results suggest an inverse association between coffee drinking, alcohol consumption and PD. The multiple inverse association observed may indicate a complex interaction between genetic and environmental factors.

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Akinesia due to catecholamine depletion in mice is prevented by caffeine. Further evidence for an involvement of adenosinergic system in the control of motility

Cited by 22 publications

References 8 publications

Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons

Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study

A Case-Control Study on Cigarette, Alcohol, and Coffee Consumption Preceding Parkinson’s Disease

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