AKEntAnnos. The Sardinia Study of Extreme Longevity

Deiana, Luca; Ferrucci, Luigi; Pes, Giovanni Mario; Carru, Ciriaco; Delitala, G.; Ganau, Antonello; Mariotti, Stefano; Nieddu, Antonio; Pettinato, S.; Putzu, P.; Franceschi, Claudio; Baggio, G.

doi:10.1007/bf03399655

Cited by 68 publications

(66 citation statements)

References 25 publications

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“…Si vous lancez une recherche sur Internet avec les mots « secret » et « longévité », les résultats seront plus que nom breux. Toutes sortes de sites dévoilent des secrets de longévité, en rapport avec l'alimentation, l'activité phy sique, l'air pur, l'eau de source, le cadre familial et affectif… Des secrets s'abriteraient aussi sous le ciel de certaines régions, telles la Sardaigne ou l'île d'Okinawa, au Japon : l'air des montagnes et un régime alimentaire spécifi que seraient propices au grand âge (Deiana et al, 1999;Lio et al, 2003). Bref, la liste des causes supposées de la longévité est vaste et les études variées, quoique pas toujours sérieuses.…”

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Hérédité et longévité au Québec ancien*

Blackburn

Bourbeau

Desjardins

2005

cqd

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Par l’entremise du Registre de la population du Québec ancien (RPQA), banque de données élaborée dans le cadre du Programme de recherche en démographie historique, nous avons observé l’existence d’une composante familiale de la longévité. En effet, l’âge au décès des parents semble influencer l’âge au décès de leurs fils et filles, particulièrement pour les parents décédés après 70 ans. Nous avons aussi observé une convergence significative de l’âge au décès dans les fratries. Cependant, il existe également une relation entre les âges au décès des conjoints, ce qui laisse supposer que la composante familiale est due à la part environnementale de l’héritabilité plutôt qu’à la part génétique.For a long time, people have had a belief in a form of heritability in regard to longevity. According to this belief, reaching very great ages would be specific to some families. By using the Registre de la population du Québec ancien (RPQA), a database put together by the Programme de recherche en démographie historique (PRDH), we have established the existence of a familial component of human longevity. Indeed, our results suggest that the parents’ ages at death could have had a significant influence on their children’s ages at death, particularly for parents who died at age 70 or over. Moreover, our analysis revealed a significant association between brothers’ and sisters’ ages at death. However, there is also a clear relationship between spouses’ ages at death, which implies that the familial component of longevity could be more strongly related to the environmental component of heritability than to its genetic component

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Hérédité et longévité au Québec ancien*

Blackburn

Bourbeau

Desjardins

2005

cqd

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“…was carried out between January 1st and December 31st 1997 (Deiana et al, 1999). One hundred forty-one centenarians underwent a full interview and 129 donated a blood sample.…”

Section: Subjects and Study Designmentioning

confidence: 99%

“…The birth date of centenarians was checked by matching information from the census registry, the baptism registry of the local parish archive, the social security document, and the testimony of a first-degree relative. The Sardinian centenarians display a men/women ratio of 1:2 instead of the most common 1:4-1:10 ratio (Deiana et al, 1999;Franceschi et al, 2000). For each centenarian, a 60-year (±1 year) old control of the same gender was randomly selected from the inhabitants of the same province.…”

Section: Subjects and Study Designmentioning

confidence: 99%

Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians

Scola

Lio

Candore

et al. 2008

Experimental Gerontology

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Some genetic determinants of longevity might reside in those polymorphisms for the immune system genes that regulate immune responses. Many longevity association studies focused their attention on HLA (the human MHC) polymorphisms, but discordant results have been obtained. Sardinians are a relatively isolate population and represent a suitable population for association studies. Some HLA-DR and DQ alleles form very stable haplotypes with a strong linkage disequilibrium. In a previous study on Sardinian centenarians we have suggested that HLA-DRB1 * 15 allele might be marginally associated to longevity. HLA-DR,DQ haplotypes are in strong linkage disequilibrium and well conserved playing a role in the association to diseases. Hence, we have evaluated, by amplification refractory mutation system/polymerase chain reaction (ARMS-PCR) the HLADQA1 and HLA-DQB1 allele frequencies in 123 centenarians and 92 controls from Sardinia to assess whether the association to HLA-DRB1 * 15 allele may be due to the other genes involved in the HLA-DR,DQ haplotypes. The frequencies of HLA-DQA1,DQB1 haplotypes were not significantly modified in centenarians. Nevertheless by evaluating the frequency of DRB1 * 15 linked haplotypes, we observed a not significant increase in centenarians of HLA-DQA1 * 01,DQB1 * 05 and HLA-DQA1 * 01,DQB1 * 06 haplotypes. These data suggest that these haplotypes might have a role in determining life span expectancy and longevity.

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“…Among those able to reach the extreme limits of life, centenarians represent an example of successful aging, due probably to their genotypes and to peculiar neuro-immuno-endocrine mechanisms (Mariotti et al, 1992;Sansoni et al, 1993;Franceschi et al, 1995;Mari et al, 1996;De Benedictis et al, 1997;Baggio et al, 1998;Deiana et al, 1999;Fagnoni et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Calcium metabolism and vitamin D in the extreme longevity

Passeri

Vescovini

Sansoni

et al. 2008

Experimental Gerontology

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Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence. Calcium metabolism is regulated at cellular/molecular level by a network of cytokines, growth factors, systemic hormones that act on bone in paracrine/autocrine/ systemic fashion. Among the molecules involved in bone metabolism, parathyroid hormone (PTH) and vitamin D present some peculiar aspects during senescence. The osteometabolic features in a consistent group of centenarians have been evaluated. It results that a severe hypovitaminosis D was present in 99 out of 104 centenarians (25-OH vitamin D below 5 nmol/L), and that it plays an important role as a factor inducing a vicious circle involving hypocalcemia, secondary hyperparathyroidism, together with biochemical features indicating a consistent bone loss. Serum C-terminal cross-linking telopeptide, a specific marker of bone resorption was elevated in 92% of these subjects. Moreover, it has been found that several femoral fractures had occurred after 90 years of age. These data offer a rational for the possible prevention of elevated bone turnover, bone loss and consequently the reduction of osteoporotic fractures and fractures-induced disability, in the oldest olds, through the simple supplementation with calcium and vitamin D.

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AKEntAnnos. The Sardinia Study of Extreme Longevity

Cited by 68 publications

References 25 publications

Hérédité et longévité au Québec ancien*

Hérédité et longévité au Québec ancien*

Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians

Calcium metabolism and vitamin D in the extreme longevity

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