Akciğer Kanserli Hastalarda F-18 FDG PET/BT Parametrelerinin Klinik Evre ile İlişkisi

Erol, Mustafa; Önner, Hasan; Taştekin, Güngör

doi:10.30733/std.2020.01475

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TLG was found a better prognostic predictor than SUVmax in many studies that involved both PDAC and different cancers (14,15). In line with previous studies (6,17), we found that SUVmax was not an independent predictive factor of overall survival in our study.…”

Section: Discussionsupporting

confidence: 85%

Evaluation of Overall Survival Predictions In Inoperable Pancreas Ductal Adenocarcinoma

Erol¹,

Önner²,

Küçükosmanoğlu³

2022

Genel Tıp Dergisi

Self Cite

View full text Add to dashboard Cite

Objective: In this study, we aimed to determine the independent predictive parameters of overall survival (OS) of patients with inoperable pancreatic ductal adenocarcinoma (PDAC) and to investigate whether these parameters can be used as potential biomarkers to shape precision medicine practices for PDAC patients. Material and Methods:The clinical and pathological data of patients who were diagnosed with inoperable pancreatic ductal adenocarcinoma between January 2016 and December 2019 and who underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in our department were retrospectively analyzed. Tumor diameter, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were calculated from FDG PET/CT images. Univariate and multivariate Cox regression analyzes were performed to investigate the variable affecting overall survival. Overall survival data were analyzed using the Kaplan-Meier method, using the log-rank test. Results: A total of 48 patients, 31 male and 17 female, with a mean age of 65.85 ± 1.64 were included in the study. In univariate Cox regression analyzes were performed to examine the factor affecting OS. Clinicopathological factors (tumor localization, tumor diameter, stage) and FDG PET/CT parameters (SUVmax, MTV and TLG) with a p-value of < 0.2 were compared to multivariate Cox regression analysis. TLG was found to be the only independent predictor of OS. In the Kaplan-Meier analysis, the median OS duration of the patients with a median value of TLG below 298.34 was 13.87 months, while the median OS duration was found to be 4.97 months in patients with a TLG value above this value. Conclusion: In our study, TLG value, which is an FDG PET/CT parameter that reflects both the metabolic activity and the volume of the tumor, was found to be the only independent predictor of the OS of inoperable PDAC patients. TLG can be used as a potential biomarker for survival in patients with inoperable PDAC and may assist precision medicine applications.

show abstract

Section: Discussionsupporting

confidence: 85%

Evaluation of Overall Survival Predictions In Inoperable Pancreas Ductal Adenocarcinoma

Erol¹,

Önner²,

Küçükosmanoğlu³

2022

Genel Tıp Dergisi

Self Cite

View full text Add to dashboard Cite

show abstract

Küçük Hücre Dışı Akciğer Kanserli Hastalarda FDG PET/BT Parametrelerinin Evre Ve Patolojik Veriler İle İlişkisi

MAMAN,

DEMİRTAŞ

2024

Hitit Medical Journal

View full text Add to dashboard Cite

Amaç: Akciğer kanserli hastaların pozitron emisyon tomografisi/bilgisayarlı tomografisi (PET/BT) görüntülerinden elde edilen primer lezyonun maksimum standartlaştırılmış alım değeri (SUVmax), SUVmean, metabolik tümör hacmi (MTV) ve total lezyon glikolizi (TLG) değerlerinin hastalık evresi ve patolojik verilerle ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Tıp Fakültesi Nükleer Tıp Anabilim Dalında 2020-2023 tarihleri arasında akciğer kanseri tanısı ve evreleme amacıyla PET/BT görüntülemesi yapılan, histopatolojik olarak akciğer kanseri tanısı olan toplam 81 hasta çalışmaya alındı. Hastaların PET/BT görüntülerinden elde edilen primer lezyonun, SUVmax, SUVmean, MTV ve TLG değerleri ile patolojik veriler not edildi. Küçük hücre dışı akciğer kanseri (KHDAK) tanısı alan hastaların PET/BT görüntüleri kullanılarak patolojik veriler eşliğinde TNM evreleme sistemine göre evrelendirildi. Veriler SPSS 20.0 programı ile analiz edildi. Bulgular: Çalışmaya alınan 66 erkek ve 15 kadın toplam 81 hastanın ortalama yaşı 60±10 (26-78) olarak hesaplanmıştır. Bu çalışmada, KHDAK tanılı hastalar evreleme PET/BT’nin yarı-kantitatif SUVmax, SUVmean, MTV ve TLG değerleri ile ilişkisi analiz edildi. Yaptığımız araştırmaya göre, plevral invazyon, lenf nodu metastazı, tümör çapı ve TNM evre ile SUVmax, SUVmean, MTV ve TLG değerlerinde istatistiksel olarak anlamlı farklılıklar olduğu görüldü(P

show abstract

Akciğer Kanserli Hastalarda F-18 FDG PET/BT Parametrelerinin Klinik Evre ile İlişkisi

Cited by 2 publications

References 0 publications

Evaluation of Overall Survival Predictions In Inoperable Pancreas Ductal Adenocarcinoma

Evaluation of Overall Survival Predictions In Inoperable Pancreas Ductal Adenocarcinoma

Küçük Hücre Dışı Akciğer Kanserli Hastalarda FDG PET/BT Parametrelerinin Evre Ve Patolojik Veriler İle İlişkisi

Contact Info

Product

Resources

About