AJMQ Newsletter

Abstract

Each year, the American College of Medical Quality (ACMQ) has held its traditional Quality Institute at the Annual Meeting. Over the past 5 years, the nature and format of the Quality Institute has evolved into one of the best attended and highly rated sessions. The Annual Meeting Committee has supported the move away from passive lecturing to a lively, interactive, and timely case study format that involves negotiation and problem solving within small groups of participants. The Case Study method has evolved over the past 30 years as a very effective and proven learning method that is now used widely in business schools and other post-graduate degree programs.The Institute has attracted highly regarded national expert faculty, who provide firm and factual foundations for small group learning. Some of our guest faculty have included nationally recognized quality leaders, Drs

Synthesis and <i>in Vivo</i> Evaluation of Novel Quinoline Derivatives as Phosphodiesterase 10A Inhibitors

“…The organic layer was washed with saturated NaHCO 3 aqueous solution and brine, dried over MgSO 4 , filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (0-5% MeOH in EtOAc) to give a colorless oil (28 mg), which was dissolved in EtOAc (3.8 mL) and 4 M HCl/EtOAc (85 µL, 0.34 mmol) was added to the mixture.…”

“…To the residue in ethanol (2.0 mL) were added 2-vinylquinoline (100 mg, 0.65 mmol) and acetic acid (30 µL, 0.53 mmol), and the mixture was stirred at 80°C for 12 h. After cooling at room temperature, the mixture was partitioned between saturated NaHCO 3 aqueous solution and EtOAc. The organic layer was washed with brine, dried over MgSO 4 , filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (1-10% MeOH in CHCl 3 ) to give a pale brown solid, which was dissolved in MeOH (5.0 mL) and 4 M HCl/dioxane (0.25 mL, 1.00 mmol) was added to the mixture.…”

“…1) However, most current therapeutic treatments primarily address positive symptoms with only limited efficacy on negative symptoms and cognitive dysfunction. In addition, these existing antipsychotics frequently cause undesirable side effects such as extrapyramidal syndrome, weight gain, diabetes and QT prolongation, [2][3][4][5] highlighting the unmet medical needs for drugs less prone to such side effects.…”