Airway Wall Thickness in Cigarette Smokers: Quantitative Thin-Section CT Assessment

Berger, Patrick; Pérot, Vinçent; Desbarats, Pascal; Tunon-de-Lara, José-Manuel; Marthan, Roger; Laurent, François

doi:10.1148/radiol.2353040121

Cited by 135 publications

(116 citation statements)

References 28 publications

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“…In COPD, the quantitative evaluation of the airways using CT has received less attention than the analysis of emphysema. In fact, there have been only a few such studies (27)(28)(29)(30). Nakano and colleagues were the first to report that wall thickening at B1 in the right upper lobe had a significant correlation with FEV 1 (% predicted) (27), and they subsequently demonstrated that measuring airway dimensions in large airways could roughly estimate small airway dimensions by comparing the CT findings of large airways with the histologic measurement of small airways in lungs excised from the same subjects (28).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it has been suggested that CT can be used to evaluate airway dimensions in a variety of diseases (21)(22)(23)(24)(25)(26). However, there have been only a few studies that have focused on measuring the airway dimensions in patients with COPD (27)(28)(29)(30). Nakano and colleagues were the first to report that wall thickening in the apical bronchus of the right upper lobe had a significant correlation with FEV 1 (% predicted) in patients with COPD (27).…”

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confidence: 99%

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Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease

Hasegawa

Nasuhara

Onodera

et al. 2006

Am J Respir Crit Care Med

371

352

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Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography. Conclusions:We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD is more closely related to the dimensions of the distal (small) airways than proximal (large) airways.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease

Hasegawa

Nasuhara

Onodera

et al. 2006

Am J Respir Crit Care Med

371

352

View full text Add to dashboard Cite

show abstract

“…Rays that project into the neighboring blood vessel have been manually removed. Modified by permission from Reference 44. general was associated with thicker airway walls and showed that subjects with COPD had thicker airway walls than smokers or nonsmokers without COPD (41). A study by Aziz and coworkers used a combination of quantitative CT analysis, qualitative texture assessment, and qualitative airway analysis to assess the different morphologic features present in subjects with COPD (41).…”

Section: Phenotyping Of Copd Using Computed Tomographymentioning

confidence: 99%

Quantitative Computed Tomography Assessment of Airway Wall Dimensions: Current Status and Potential Applications for Phenotyping Chronic Obstructive Pulmonary Disease

Coxson

2008

Proceedings of the American Thoracic Society

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Airway remodeling is extremely important in the pathophysiology of chronic obstructive pulmonary disease (COPD). Since the site and nature of airflow obstruction was described by Hogg, Thurlbeck, and Macklem, investigators have been looking for methods to noninvasively measure the airway wall dimensions in subjects with and at risk for COPD. The advent and proliferation of computed tomography (CT) initially allowed investigators to quantify changes in lung parenchymal structure in subjects with emphysema, and more recently attention has turned to the measurement of airway wall dimensions. Unfortunately, while the lung density is relatively easy to quantify, reliable airway measurements have proven to be more difficult to obtain. However, recent advances in CT technology and new computer algorithms have changed the way investigators have measured airways using CT, and it is now hoped that many of the early issues surrounding airway measurements can be resolved. The measurement of airway wall dimensions is important because it is well known that chronic airflow limitation can be caused by a combination of airway and parenchymal changes. The phenotypic expression of these different subtypes of COPD is vital because a therapy designed to modulate the inflammation in airways may be contraindicated in subjects with the emphysema phenotype and visa versa. Therefore, these new imaging techniques are very likely to play a front-line role in the study of COPD and will, hopefully, allow clinicians to phenotype individuals, thereby personalizing their treatment.

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“…Matsouka et al have studied with a healthy group. Berger et al have also demonstrated that in vivo normalized airway wall thickness was larger in smokers with COPD than it was in smokers or nonsmokers without COPD 22) . Therefore age and smoking should be taken into consideration in case of measurement of bronchus wall in larger series due to the controversies in previous studies.…”

Section: Discussionmentioning

confidence: 94%

Bronchial Wall Thickness in Toll Collectors

et al. 2010

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There is an increasing concern about the possible adverse effects of diesel exhaust particulates (DEP) on human health. Diesel exhaust is one of the major contributors to particulate air pollution in cities. DEP air pollution is a mixture of solid particles and liquid droplets mainly included carbon monoxide, nitrogen dioxides and volatile organic compounds (VOCs) [1][2][3] . There are a considerable number of epidemiological studies demonstrating a significant relationship between road traffic pollution and an increase in asthma exacerbations and incidence of allergy in both adults and children [4][5][6][7][8] . Some associations between autovehicle traffic and lung function reduction, increased respiratory symptoms, increased mortality from respiratory diseases, reduced exercise tolerance were also reported previously 9) .Limited number of studies has focused on the radiographical changes related to the air pollution included diesel exhaust. Chest X-rays of children in Mexico City demonstrated bilateral hyperinflation (151/230) and increased linear markings (121/230). These findings were consistent with bronchiolar, peribronchiolar and/or alveolar duct inflammation, possibly caused by ozone, particulate matter (PM) and lipopolysaccharide exposure. Authors suggested that the epidemiological implications of these findings were important for children residing in polluted environments, because bronchiolar disease could lead to chronic pulmonary disease later in life 10) . Airway lumen and airway wall areas may be quantitatively assessed on CT images by using specific techniques that must be reproducible as well as accurate in order to compare the airways pre-and post-intervention (bronchoprovocation, bronchodilatation, therapeutic response) and to carry out longitudinal studies of airway remodeling 11) . Airway lumen and airway wall areas have been well investigated in asthmatic patients and in patients diagnosed as Chronic Obstructive Lung Disease (COPD). Few studies have focused on air pollution related changes Abstract: There is an increasing concern about the possible adverse effects of diesel exhaust particulates on human health. In a diesel exposed occupational group composed of 120 toll collectors, a cross-sectional study was performed to evaluate the chest radiographs and 40 toll collectors were selected for computed tomography examination according to

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Airway Wall Thickness in Cigarette Smokers: Quantitative Thin-Section CT Assessment

Abstract: This software provides accurate and reproducible measurements of IA and WA of bronchi on thin-section CT images and demonstrates that in vivo normalized airway wall thickness was larger in smokers with COPD than it was in smokers or nonsmokers without COPD.

Cited by 135 publications

References 28 publications

Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease

Airflow Limitation and Airway Dimensions in Chronic Obstructive Pulmonary Disease

Quantitative Computed Tomography Assessment of Airway Wall Dimensions: Current Status and Potential Applications for Phenotyping Chronic Obstructive Pulmonary Disease

Bronchial Wall Thickness in Toll Collectors

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