Airway remodeling assessed by quantitative computed tomography at various stages of asthma severity defined according to Global Initiative for Asthma report: a single-center study

Obojski, Andrzej; Patyk, Mateusz; Zaleska-Dorobisz, Urszula

doi:10.20452/pamw.16152

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Bronchial WT (BWT) and emphysema are more common in patients with severe asthma compared to mild asthma [125,[133][134][135]. However, other studies have not found a link with the severity of asthma [133,136,137]. WT% is a meaningful radiological marker in assessing lung function changes in asthma.…”

Section: Radiological Indicators For Assessing Severity Early Identif...mentioning

confidence: 99%

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Baglivo,

Quaranta,

Dragonieri

et al. 2024

Preprint

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Epithelial barrier damage plays a central role in the development and maintenance of allergic inflammation. The rise in airways epithelial barrier permeability alters the tissue homeostasis and allows the allergen and other external agents penetration. Different factors contribute to barrier impairment, such as eosinophilic infiltrate and allergens proteases action: the eosinophilic cationic proteins and the allergens' proteolytic activity have a central role in contributing to epithelial damage. In the airways, the allergens proteases degrade the epithelial junctional proteins allowing the allergen penetration and the uptake by dendritic cells. The increase in allergen-immune system interactions induce the release of the alarmins and the activation of type 2 inflammatory pathways causing, or worsening, the main symptoms at skin, bowel and respiratory levels. We aim to highlight the molecular mechanisms underlying allergenic proteases-induced epithelial barrier damage and the role of immune response in allergic asthma onset, maintenance and progression. We further will explore clinical and radiological potential biomarkers of airways remodeling in allergic asthma patients.

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Section: Radiological Indicators For Assessing Severity Early Identif...mentioning

confidence: 99%

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Baglivo,

Quaranta,

Dragonieri

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Bronchial WT (BWT) and emphysema are more common in patients with severe asthma compared to those with mild asthma [125,[133][134][135]. However, other studies have not found a correlation with the severity of asthma [133,136,137]. WT% is a meaningful radiological marker in assessing lung function changes in asthma.…”

Section: Radiological Indicators For Assessing Severity Early Identif...mentioning

confidence: 99%

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Baglivo,

Quaranta,

Dragonieri

et al. 2024

IJMS

View full text Add to dashboard Cite

Epithelial barrier damage plays a central role in the development and maintenance of allergic inflammation. Rises in the epithelial barrier permeability of airways alter tissue homeostasis and allow the penetration of allergens and other external agents. Different factors contribute to barrier impairment, such as eosinophilic infiltration and allergen protease action—eosinophilic cationic proteins’ effects and allergens’ proteolytic activity both contribute significantly to epithelial damage. In the airways, allergen proteases degrade the epithelial junctional proteins, allowing allergen penetration and its uptake by dendritic cells. This increase in allergen–immune system interaction induces the release of alarmins and the activation of type 2 inflammatory pathways, causing or worsening the main symptoms at the skin, bowel, and respiratory levels. We aim to highlight the molecular mechanisms underlying allergenic protease-induced epithelial barrier damage and the role of immune response in allergic asthma onset, maintenance, and progression. Moreover, we will explore potential clinical and radiological biomarkers of airway remodeling in allergic asthma patients.

show abstract

Follistatin-related protein 1 in asthma: miR-200b-3p interactions affect airway remodeling and inflammation phenotype

Liu

Zhang

et al. 2022

International Immunopharmacology

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Airway remodeling assessed by quantitative computed tomography at various stages of asthma severity defined according to Global Initiative for Asthma report: a single-center study

Cited by 3 publications

References 18 publications

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma

Follistatin-related protein 1 in asthma: miR-200b-3p interactions affect airway remodeling and inflammation phenotype

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