Airway obstruction secondary to tracheobronchial involvement of asymptomatic undiagnosed Crohn's disease in a pediatric patient

Ahmed, Khwaja Asif; Thompson, J. W.; Joyner, Royce; Stocks, Rose Mary S.

doi:10.1016/j.ijporl.2005.02.004

Cited by 21 publications

(11 citation statements)

References 9 publications

(12 reference statements)

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“…Tracheobronchial involvement of Crohn's disease is extremely rare and can present with airway obstruction. 37,38 For example, diffuse luminal narrowing of the subglottic trachea to the proximal main bronchus was reported on a CT scan of a young woman with Crohn's disease, which corresponded to the histologic features of nonspecific acute and chronic tracheiitis. 37 Large airway involvement is a rare extraintestinal manifestation of ulcerative colitis.…”

Section: Chronic Inflammatory Bowel Diseasementioning

confidence: 99%

Large Airway Diseases

Kang

2011

Journal of Thoracic Imaging

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Various neoplasms and nonneoplastic diseases affect the tracheobronchial tree and cause focal or diffuse airway luminal narrowing or dilatation. For the identification and characterization of various large airway diseases, imaging, particularly computed tomography, plays a key role. Advances in computed tomography technology and postprocessing techniques enable the rapid, noninvasive, comprehensive, and accurate evaluation of the tracheobronchial tree. This article provides a radiologic review of various large airway diseases, including congenital tracheobronchial abnormalities such as infection, inflammation, and infiltrative diseases causing large airway narrowing with wall thickening; tracheal stricture; tracheal neoplasm; bronchiectasis; broncholithiasis; and bronchial anthracofibrosis.

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Section: Chronic Inflammatory Bowel Diseasementioning

confidence: 99%

Large Airway Diseases

Kang

2011

Journal of Thoracic Imaging

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“…This may be because the inflammatory response is amplified differently in the respiratory tract and GI tract, even though it may be triggered by the same antigen in both locations [ 3 , 11 ]. Patients are usually diagnosed with CD before presentation of pulmonary manifestations; however, airway involvement has been reported in patients without a diagnosis of CD [ 15 ]. Pathologically, airway infiltration by inflammatory cells and mucosal ulceration may occur.…”

Section: Discussionmentioning

confidence: 99%

Tracheal Involvement in Crohn Disease: the First Case in Korea

Park

Kim

et al. 2016

Clin Endosc

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Respiratory involvement in Crohn disease (CD) is rare condition with only about a dozen reported cases. We report the first case of CD with tracheal involvement in Korea. An 18-year-old woman with CD was hospitalized because of coughing, dyspnea, and fever sustained for 3 weeks. Because she had stridor in her neck, we performed computed tomography of the neck, which showed circumferential wall thickening of the larynx and hypopharynx. Bronchoscopy revealed mucosal irregularity, ulceration, and exudates debris in the proximal trachea, and bronchial biopsy revealed chronic inflammation with granulation tissue. Based on these findings, we suspected CD with tracheal involvement and began administering intravenous methylprednisolone at 1 mg/kg per day, after which her symptoms and bronchoscopic findings improved.

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“…In refractory cases procedures like laser beam, balloon dilatation, stent placement or tracheotomy may be necessary to maintain patent airway. 10 , 11 , 12 , 13 , 20 , 21 , 22 , 23 , 24 According to our experience, in the first case the girl had evolution to respiratory failure in spite of inhaled corticosteroid therapy. This highlights the fact that inhaled administration may not be efficient enough in severe cases.…”

Section: Discussionmentioning

confidence: 79%

Tracheitis – A Rare Extra-Intestinal Manifestation of Ulcerative Colitis in Children

Nunes

Abreu

Corujeira

et al. 2016

GE Portuguese Journal of Gastroenterology

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IntroductionInflammatory bowel disease may cause both intestinal and extraintestinal manifestations. Respiratory symptoms in ulcerative colitis are rare and tracheal involvement is exceedingly rare in children.Case 1Sixteen year-old female with a 4-week-complaint of abdominal pain, bloody diarrhea, fever and cough. The investigation was consistent with the diagnosis of concomitant ulcerative colitis/coinfection to Escherichia coli. On day 4 respiratory signs persisted so azithromycin and inhaled corticosteroids were added. By day 6 she progressed to respiratory failure and was diagnosed with necrotic tracheitis so started on intravenous steroids with fast clinical improvement.Case 2Twelve-year-old male adolescent with ulcerative colitis and sclerosing cholangitis started dry cough and throat pain 10 days after diagnosis. Laboratory investigations showed increased inflammatory signs and normal chest X-ray. He started treatment with azithromycin without clinical improvement and on day five he presented dyspnea and fever. Laryngeal fibroscopy suggested tracheitis and so systemic steroids where added with fast clinical and analytic improvement.DiscussionTracheitis should be suspected if there are persistent respiratory symptoms even when exams are normal. Early recognition and early treatment are essential for a good prognosis preventing progression to respiratory failure.

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Airway obstruction secondary to tracheobronchial involvement of asymptomatic undiagnosed Crohn's disease in a pediatric patient

Cited by 21 publications

References 9 publications

Large Airway Diseases

Large Airway Diseases

Tracheal Involvement in Crohn Disease: the First Case in Korea

Tracheitis – A Rare Extra-Intestinal Manifestation of Ulcerative Colitis in Children

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