Airway management in trauma

Abstract

Trauma has assumed epidemic proportion. 10% of global road accident deaths occur in India. Hypoxia and airway mismanagement are known to contribute up to 34% of pre-hospital deaths in these patients. A high degree of suspicion for actual or impending airway obstruction should be assumed in all trauma patients. Objective signs of airway compromise include agitation, obtundation, cyanosis, abnormal breath sound and deviated trachea. If time permits, one should carry out a brief airway assessment prior to undertaking definitive airway management in these patients. Simple techniques for establishing and maintaining airway patency include jaw thrust maneuver and/or use of oro- and nas-opharyngeal airways. All attempts must be made to perform definitive airway management whenever airway is compromised that is not amenable to simple strategies. The selection of airway device and route- oral or -nasal, for tracheal intubation should be based on nature of patient injury, experience and skill level.

Synthesis of Diabetic II Inhibitors Based on 2-mercaptobenzimidazole and their Molecular Docking Study

“…Intermediate product I was reacted and refluxed with intermediate product II in methanol in the presence of acetic acid to give 2-mercaptobenzimidazole bearing sulfonamide analogs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). another phenyl ring.…”

“…Docking study was done targeting the crystal structure of amylase (PDB ID: 4W93) [30] in order to reveal the binding modes of synthesized derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). For the purpose of docking studies, protein preparation module in discovery studio 2018 (Dassault systemes BIOVIA, USA) was used to optimize the crystal structure of amylase [31].…”

“…Charges, hydrogen bond and missing atom were computed. Built and ligand preparation module implemented in discovery studio 2018 (Dassault systems BIOVIA, USA) was used to prepared and optimized the docking study of the synthesized analogs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Gold docking tool was used for the purpose of docking, ligand preparation comprises stereochemistry, assigning bond order and various tautomer.…”

“…Both natural and synthetic benzimidazole derivatives attracted scientific interest due to significant biological activities such as antifungal [7], anti-inflammatory [8], analgesic [9], antibacterial [10], CNS depressant [11], anti-HIV [12] and anthelmintic [13].…”

Chest Trauma: An Overview

“…The primary goal is to provide adequate oxygenation and prevent further damage. Possible airway obstructions need to be correct, start mask ventilation and tracheal intubation with protective airway maneuvers and rapid sequence [56].…”