Airway invasion in non-neurologically ill patients with dysphagia

Kim, Kang Lip; Park, Gi-Young; Kwon, Dong Rak; Kwon, Do Yun; Kwak, Sang Gyu; Cho, Hee Kyung

doi:10.1097/md.0000000000022977

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Dysphagia is a growing concern for the health of older and multimorbid patient populations, as it tends to remain an underestimated symptom [ 27 , 28 , 29 ]. Previous findings suggested that 46% of patients with dysphagia do not inform their doctor regarding their condition, while 70.4% of patients are not properly diagnosed as having dysphagia [ 30 ].…”

Section: Swallowing Problems In the Older Patient Populationmentioning

confidence: 99%

Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience

Drumond

Stegemann

2020

Pharmaceutics

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Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care. There is clear evidence for a growing number of clinically relevant swallowing issues (e.g., dysphagia) in the older patient population, especially when considering the multimorbid, frail, and polymedicated patients. Swallowing impairments have a negative impact on SODF administration, which leads to poor adherence and inappropriate alterations (e.g., crushing, splitting). Different strategies have been proposed over the years in order to enhance the swallowing experience with SODF, by using conventional administration techniques or applying swallowing aids and devices. Nevertheless, new formulation designs must be considered by implementing a patient centric approach in order to efficiently improve SODF administration by older patient populations. Together with appropriate SODF size reductions, innovative film coating materials that can be applied to SODF and provide swallowing safety and efficacy with little effort being required by the patients are still needed. With that in mind, a literature review was conducted in order to identify the availability of patient centric coating materials claiming to shorten esophageal transit times and improve the overall SODF swallowing experience for older patients. The majority of coating technologies were identified in patent applications, and they mainly included well-known water soluble polymers that are commonly applied into pharmaceutical coatings. Nevertheless, scientific evidence demonstrating the benefits of given SODF coating materials in the concerned patient populations are still very limited. Consequently, the availability for safe, effective, and clinically proven solutions to address the increasing prevalence of swallowing issues in the older patient population is still limited.

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Section: Swallowing Problems In the Older Patient Populationmentioning

confidence: 99%

Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience

Drumond

Stegemann

2020

Pharmaceutics

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Effect of neuromuscular electrical stimulation associated with swallowing-related muscle training for post-stroke dysphagia

Zhang

et al. 2021

Medicine

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Background: Swallowing dysfunction is a common dysfunction after stroke, and its incidence exceeds 50%. Aspiration pneumonia and malnutrition induced by dysphagia not only cause psychological shock to patients after stroke, but also burden the medical payment. Neuromuscular electrical stimulation, which stimulates the cortex and cortical bulb pathways to improve swallowing function, has been one of the emerging treatments for the post-stroke deglutition disorder. These therapy operators require the proficiency in professional knowledge, limiting clinical large sample studies, so there is an absence of evidence-based medicine. The research is to evaluate the effectiveness of neuromuscular electrical stimulations combined with swallowing-related muscle training to treat swallowing dysfunction after stroke. Methods: Computer retrieval performed in the 9 databases, including PubMed, Embase, Web of science, Cochrane Library, ClinicalTrials, China Biomedical Literature Database (CBM), China Knowledge Network Database (CNKI), Wanfang Database (WanFang), and China VIP Database (VIP). Taking the published literature from the establishment of the database until December 20, 2020. Literature searching is related to neuromuscular electrical stimulation randomized controlled trials on the effect of swallowing in stroke. In addition, we will do the manual search in Baidu Academic and Google Academic database as a supplementary search. The correlative randomized controlled clinical studies retrieval time range from the establishment of the database to December 20, 2020. Two investigators will screen the literature according to the inclusion and exclusion criteria independently, during that period they will evaluate the quality of the included studies and extract data from studies. The extracted data are dichotomous data will be represented by relative risk, continuous data will be represented by mean difference or standard mean deviation. If there exists heterogeneity and the final data summary analysis select random effect model. On the contrary, the fixed effect model is selected. Then, RevMan5.3 software was used when analyzing included literature. Meanwhile, the analysis results were illustrated by drawing. Results: This review will summarize available trials aimed at providing a comprehensive estimation of effectiveness of neuromuscular electrical stimulation associated with swallowing muscle training for post-stroke dysphagia. Conclusion: This review based on a comprehensive analysis of currently published randomized controlled trials on post-stroke dysphagia, that provide reliable evidence-based medicine evidence for the efficacy of neuromuscular electrical stimulation associated with swallowing rehabilitation training. Registration number: INPLASY202110009.

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Endoscopic-assisted lateral neck dissection and open lateral neck dissection in the treatment of lateral neck lymph node metastasis in papillary thyroid carcinoma: A comparison of therapeutic effect

Ma¹,

Zhang

Huang³

et al. 2022

Pak J Med Sci

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Objectives: To compare the therapeutic effect of endoscopic-assisted lateral neck dissection and open lateral neck dissection in the treatment of lateral neck lymph node metastasis of patients with papillary thyroid carcinoma (PTC). Methods: A retrospective analysis was carried out focusing on the general clinical data of 86 patients with PTC treated Baoding No.1 Central Hospital from January 2020 to September 2021. According to different surgical methods, enrolled patients were divided into the endoscopic surgery group (n = 34) and the open surgery group (n = 52). Further comparison was performed on the operation indexes [operation time, postoperative length of stay in hospital, number of dissected lymph nodes (central area, lateral cervical area), number of metastatic lymph nodes (central area, lateral cervical area), hospitalization cost], postoperative complications, postoperative neck pain, neck numbness discomfort score, and satisfaction with postoperative cosmetic effect. Results: The operation time and hospitalization cost of the endoscopic surgery group were higher than those of the open surgery group, and the intraoperative blood loss was lower than that of the open surgery group, with statistically significant differences (p<0.05). There was no significant difference in the length of stay in the hospital, the number of dissected lymph nodes, the number of metastatic lymph nodes and the detection rate of lymph nodes in zone II between the two groups (p>0.05). Furthermore, a statistically significant difference was observed in the incidence of postoperative complications between the two groups, which was lower in the endoscopic surgery group (29.4%) than that in the open surgery group (51.9%) (p<0.05). There was no significant difference in postoperative neck pain scores between the two groups (p>0.05). While the postoperative neck numbness discomfort score, and satisfaction score with postoperative cosmetic effect in the endoscopic surgery group were better than those in the open surgery group, and the difference was statistically significant (p<0.05). Conclusion: Endoscopic-assisted lateral neck dissection can reduce intraoperative blood loss and postoperative complication incidence in the treatment of lateral neck lymph node metastasis of PTC. However, it has the disadvantages of longer operation time and high hospitalization costs. doi: https://doi.org/10.12669/pjms.38.7.5826 How to cite this:Ma T, Zhang S, Huang D, Zhang G, Chen B, Zhang N. Endoscopic-assisted lateral neck dissection and open lateral neck dissection in the treatment of lateral neck lymph node metastasis in papillary thyroid carcinoma: A comparison of therapeutic effect. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5826 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Airway invasion in non-neurologically ill patients with dysphagia

Cited by 4 publications

References 31 publications

Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience

Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience

Effect of neuromuscular electrical stimulation associated with swallowing-related muscle training for post-stroke dysphagia

Endoscopic-assisted lateral neck dissection and open lateral neck dissection in the treatment of lateral neck lymph node metastasis in papillary thyroid carcinoma: A comparison of therapeutic effect

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