Abstract:Background
Preclinical studies implicate interleukin (IL)-1β as a key mediator of asthma and have shown the efficacy of IL-1 antagonism for treatment of allergic airway inflammation; human studies in this area are lacking.
Objectives
Our aim was to study the relationship of airway IL-1β to features of acute allergen-induced asthma exacerbation in humans.
Methods
Dust mite-allergic adults with mild asth… Show more
“…Although IL-1 is mainly considered as proinflammatory cytokine, one recent study showed an increased production of IL-1β after allergen challenge in asthmatics and prechallenge concentration was correlated with blood eosinophilia and FeNO. 4 Therefore, elevation of the IL-1ra observed in our study may be a reflect of regulatory mechanisms initiated by ani-IL-5 therapy.…”
Section: Cytokines In Serum Nasal Secretion and Exhaled Breath Conden...mentioning
“…Although IL-1 is mainly considered as proinflammatory cytokine, one recent study showed an increased production of IL-1β after allergen challenge in asthmatics and prechallenge concentration was correlated with blood eosinophilia and FeNO. 4 Therefore, elevation of the IL-1ra observed in our study may be a reflect of regulatory mechanisms initiated by ani-IL-5 therapy.…”
Section: Cytokines In Serum Nasal Secretion and Exhaled Breath Conden...mentioning
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