Airway Epithelial Repair by a Prebiotic Mannan Derived from <i>Saccharomyces cerevisiae</i>

Michael, Christie F.; Waters, Christopher M.; LeMessurier, Kim S.; Samarasinghe, Amali E.; Song, Chi Young; Malik, Kafait U.

doi:10.1155/2017/8903982

Cited by 14 publications

(10 citation statements)

References 27 publications

(38 reference statements)

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“…Similar results were obtained by using an in vitro model utilizing primary human BECs stimulated with the same A. fumigatus antigens (53). The mannose receptor (MR) is another C-type lectin receptor involved in fungal, and notably Aspergillus conidia, recognition and is expressed by 16HBE cells and primary BECs (54). The MR recognizes carbohydrates rich in mannose typically produced by many microorganisms including fungi (55) but its immunespecific role against A. fumigatus in association with BECs has not been investigated.…”

Section: Recognition Of Aspergillus Fumigatus By Bronchial Epithelialsupporting

confidence: 67%

Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

et al. 2020

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Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infections. The contamination occurs by inhalation of conidia present in the air, and the first encounter of this fungus in the human host is most likely with the bronchial epithelial cells. Although alveolar macrophages have been widely studied in the Aspergillus-lung interaction, increasing evidence suggests that bronchial epithelium plays a key role in responding to the fungus. This review focuses on the innate immune response of the bronchial epithelial cells against A. fumigatus, the predominant pathogenic species. We have also detailed the molecular interactants and the effects of the different modes of interaction between these cells and the fungus.

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Section: Recognition Of Aspergillus Fumigatus By Bronchial Epithelialsupporting

confidence: 67%

Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

et al. 2020

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“…Aeroallergen sensitization is also uncommon at this age, as detected in only 36/639 (5.6%) infants in this cohort, making it harder to delineate these phenotypes. A recent study by Michael et al [56] provides possible mechanistic insight on these observed protective effects on infant wheeze outcomes, as they treated lung epithelial cells with prebiotics and found facilitation of wound repair in these human bronchial epithelial cells involving mannose receptors.…”

Section: Discussionmentioning

confidence: 99%

Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease

et al. 2019

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Maternal diet during pregnancy plays a likely role in infant immune development through both direct nutrient specific immunomodulatory effects and by modulating the composition and metabolic activity of the maternal gut microbiome. Dietary fibers, as major substrates for microbial fermentation, are of interest in this context. This is the first study to examine maternal intakes of different fiber sub-types and subsequent infant allergic disease. In an observational study of 639 mother–infant pairs (all infants had a family history of allergic disease) we examined maternal intakes of total fiber, soluble fiber, insoluble fiber, resistant starch, and prebiotic fiber, by a semi-quantitative food frequency questionnaire at 36–40 weeks’ gestation. Infants attended an allergy clinical assessment at 12 months of age, including skin prick testing to common allergens. Higher maternal dietary intakes of resistant starch were associated with reduced doctor diagnosed infant wheeze, adjusted odds ratio (aOR) 0.68 (95% CI 0.49, 0.95, p = 0.02). However, in contrast, higher maternal intakes of resistant starch were associated with higher risk of parent reported eczema aOR 1.27 (95% CI 1.09, 1.49, p < 0.01) and doctor diagnosed eczema aOR 1.19 (95% CI 1.01, 1.41, p = 0.04). In conclusion, maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema.

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“…In the present study, the observed differential changes in peripheral blood leukocyte composition may serve as a surrogate for immune responses taking place in the muscle at the site of vaccination. An altered tissue responsiveness after SCFP feeding has been reported for human bronchial epithelium [ 38 ], the bovine udder [ 13 , 39 ], the bovine uterus [ 40 ], and equine joints [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Saccharomyces cerevisiae Fermentation Product (Olimond BB) Alters the Early Response after Influenza Vaccination in Racehorses

Lucassen

Finkler-Schade²,

Schuberth

2021

Animals

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Saccharomyces cerevisiae (S. cerevisiae) fermentation products (SCFP) are used in animal husbandry as pre- and postbiotic feed supplements. A variety of immunomodulatory effects are noted in many species. The purpose of this study was to test the hypothesis that horses fed with SCFP containing feed additive Olimond BB display a modulated early immune response after influenza vaccination. Six horses received Olimond BB pellets (OLI) and five horses were fed placebo pellets (PLA) for 56 days. On day 40 all horses were vaccinated with a recombinant influenza A/equi-2 vaccine. At the day of vaccination, the groups did not differ in the composition of leukocyte subpopulations and reticulocytes. Twenty-four hours after vaccination total leukocyte counts and numbers of CD4+ T-cells significantly increased in both groups. In PLA horses, the numbers of neutrophil granulocytes significantly increased and numbers of CD8+ T-cells decreased, whereas the numbers of these cell types remained unchanged in OLI horses. Only OLI horses displayed a significant increase in reticulocyte percentages after vaccination. The numbers of lymphocytes, monocytes, CD21+ B-cells, and serum amyloid A levels remained unaffected in both groups after vaccination. Sixteen days after vaccination, PLA and OLI horses differed significantly in their enhanced ELISA IgG titres against Newmarket and Florida Clade 1 influenza strains. The observed differences after vaccination suggest that feed supplementation with Olimond BB leads to modulated early immune responses after influenza vaccination, which may also affect the memory responses after booster vaccination.

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Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae

Cited by 14 publications

References 27 publications

Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease

A Saccharomyces cerevisiae Fermentation Product (Olimond BB) Alters the Early Response after Influenza Vaccination in Racehorses

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