Airway constriction in experimental asthma in dogs: tantalum bronchographic studies.

Kessler, G; Austin, James H.; Graf, P D; Gamsu, G; Gold, Warren M.

doi:10.1152/jappl.1973.35.5.703

Cited by 30 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After inhala tion of the specific nematode antigen extracts, however, Rrs was in creased and blood pressure and heart rate decreased until the dogs were treated with atropine sulfate (p<0.01) (table III). Tantalum bronchograms showed airway constriction to involve all airways outlined, maximal con striction was seen in bronchi 1-8 mm in initial diameter [18], Airway response to antisera to canine reagin. In five experiments in four dogs, Rrs increased 95 ±21% within 10 min after challenging the air ways with an aerosol containing anti-reaginic serum (p<0.001; control Rrs: 1.11 ±0.20 cm H20/l/sec) (fig.…”

Section: Pulmonary Function Studiesmentioning

confidence: 97%

Immunologic and Physiologic Characterization of the Role of Reaginic Antibodies in Experimental Asthma in Dogs

Kessler

Frick

Gold³

1974

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Examination of the role of reaginic antibodies in experimental canine asthma indicates that the immunologic species involved in the airway response to inhaled antigens in allergic dogs is in the 0.030 M DEAE-cellulose fraction, in cuts 19–21 by zone electrophoresis and in the ascending limb of the second peak by Sephadex G-200 chromatography. Reaginic activity is eliminated after heating to 56 °C for 4 h and after treatment with 2-mercaptoethanol. Reaginic activity can be transferred passively to the skin and airway of hyposensitive recipients from hypersensitive allergic dogs. Furthermore, radiolabeled antigens specifically bind to the 0.030 m DEAE-cellulose fraction which primarily contains reaginic activity. We have developed rabbit and guinea pig anti-canine reaginic sera which absorb the reaginic activity. Furthermore, we have demonstrated that rabbit antiserum can produce a reversed Prausnitz-Küstner response in both skin and airways. Because the response is completely abolished by atropine sulfate, we suggest that canine reaginic antibody produces airway constriction in the allergic dog by a vagally-mediated reflex mechanism in addition to a local effect caused by mediator release.

show abstract

Section: Pulmonary Function Studiesmentioning

confidence: 97%

Immunologic and Physiologic Characterization of the Role of Reaginic Antibodies in Experimental Asthma in Dogs

Kessler

Frick

Gold³

1974

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Bradykinin and other chemical mediators act directly on the peripheral airways and by secondary cholinergic mechanisms on both central and peripheral airways in guinea pigs (Drazen and Austen 1975). During allergic bronchoconstriction, the peripheral airway constricts maximal in contrast to the relatively uniform constriction of other airways (Kessler et al 1973). Comparison of in vitro effects of arachidonic acid metabolites on tracheal spirals and parenchymal strips revealed that peripheral airway constriction may play an important role for reactivity (Schneider and Drazen 1980).…”

mentioning

confidence: 99%

Bronchial Hyperreactivity in the Peripheral Airways.

Sasaki

Sekizawa

Yamaya

1995

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

“…Chemical mediators released from gastroin testinal organs or lungs, where an antigen-antibody reac tion has occurred, could stimulate the receptors of sensory vagal nerves. The vagal reflex has been shown to play a critical role in bronehoconstriction induced by inhaled al lergen in animals and asthmatic patients [8][9][10][11]. In the pre sent study, inhalation of atropine partially inhibited the bronehoconstriction induced by the ingested allergen.…”

Section: Discussionmentioning

confidence: 95%

Mechanisms of Bronchoconstriction after Allergen Ingestion in Sensitized Guinea Pigs

Yamada¹,

Inoue²,

Aratani³

et al. 1993

Int Arch Allergy Immunol

View full text Add to dashboard Cite

We examined whether oral administration of allergen induced bronchoconstriction in sensitized guinea pigs and investigated the mechanisms of bronchoconstriction. The animals had been immunized intraperitoneally with a mixture of Ascaris suum extract and silica gel, and exposed to ozone. They were then challenged with an oral dose of A. suum extract (6 mg/kg), and respiratory resistance (Rrs) was measured up to 7 h. After oral administration of the allergen, an increase in Rrs was observed. The mean values at 1, 3, 5 and 7 h after oral allergen challenge were 150 ± 21, 149 ± 11,151 ± 12 and 134 ± 10% of the baseline value, respectively. When saline instead of the allergen was orally administered, almost no significant increase in Rrs was observed up to 7 h. Moreover, in nonsensitized guinea pigs, oral administration of allergen produced no significant increase in Rrs for up to 7 h. When atropine was administered as an aerosol, the increase in Rrs induced by an oral allergen challenge was attenuated. Three of the five atropine-treated guinea pigs showed temporary increases in Rrs immediately after the oral allergen challenge. The mean values of Rrs in the atropine-treated animals challenged with oral allergen at 1, 3, 5 and 7 h were 106 ± 3, 106 ± 5, 115 ± 5 and 102 ± 4% of baseline value, respectively. In the animals which received oral allergen, the number of neutrophils in bronchoalveolar lavage fluid (BALF) significantly increased 2.0-fold (p < 0.05), while no significant increase in the number of eosinophils, macrophages, or lymphocytes in BALF was observed. We conclude that oral allergen challenge can induce bronchoconstriction associated with neutrophilia in BALF in sensitized guinea pigs, and that vagal reflex pathways play a role in bronchoconstriction.

show abstract

Airway constriction in experimental asthma in dogs: tantalum bronchographic studies.

Cited by 30 publications

References 0 publications

Immunologic and Physiologic Characterization of the Role of Reaginic Antibodies in Experimental Asthma in Dogs

Immunologic and Physiologic Characterization of the Role of Reaginic Antibodies in Experimental Asthma in Dogs

Bronchial Hyperreactivity in the Peripheral Airways.

Mechanisms of Bronchoconstriction after Allergen Ingestion in Sensitized Guinea Pigs

Contact Info

Product

Resources

About