Airway cilia recovery post lung transplantation

Suryadinata, Randy; Levin, Kovi; Holsworth, Lynda; Paraskeva, Miranda; Robinson, Philip

doi:10.1002/iid3.527

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Moreover, preclinical and clinical lung transplantation studies also demonstrated that Tregs and their associated mediators modulate both airway epithelium and vascular endothelium of grafted tissue, which effectively modulates the expression of various adhesion proteins on the surface of both airway epithelium and microvessels within the graft [22][23][24][25][26][27][28][29][30][31]. Inflammation-associated airway epithelial, ciliary loss, and vascular endothelial injury have been reported in various preclinical and clinical transplantation studies [22,23,[32][33][34]. FOXJ1 has been associated with ciliogenesis in airway epithelium and affected largely due to the severe hypoxic and ischemic state of the tissue [34].…”

Section: Introductionmentioning

confidence: 99%

Targeting Interleukin-10 Restores Graft Microvascular Supply and Airway Epithelium in Rejecting Allografts

Kazmi

Khan

Shamma

et al. 2022

IJMS

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Interleukin-10 (IL-10) is a vital regulatory cytokine, which plays a constructive role in maintaining immune tolerance during an alloimmune inflammation. Our previous study highlighted that IL-10 mediated immunosuppression established the immune tolerance phase and thereby modulated both microvascular and epithelial integrity, which affected inflammation-associated graft malfunctioning and sub-epithelial fibrosis in rejecting allografts. Here, we further investigated the reparative effects of IL-10 on microvasculature and epithelium in a mouse model of airway transplantation. To investigate the IL-10 mediated microvascular and epithelial repair, we depleted and reconstituted IL-10, and monitored graft microvasculature, airway epithelium, and associated repair proteins. Our data demonstrated that both untreated control allografts and IL-10 (−) allografts showed a significant early (d6) increase in microvascular leakiness, drop-in tissue oxygenation, blood perfusion, and denuded airway epithelium, which is associated with loss of adhesion protein Fascin-1 and β-catenin on vascular endothelial cells at d10 post-transplantation. However, IL-10 (+) promotes early microvascular and airway epithelial repair, and a proportional increase in endothelial Fascin-1, and β-catenin at d10 post-transplantation. Moreover, airway epithelial cells also express a significantly higher expression of FOXJ1 and β-catenin in syngrafts and IL-10 (+) allografts as compared to IL-10 (−) and untreated controls at d10 post-transplantation. Collectively, these findings demonstrated that IL-10 mediated microvascular and epithelial changes are associated with the expression of FOXJ1, β-catenin, and Fascin-1 proteins on the airway epithelial and vascular endothelial cells, respectively. These findings establish a potential reparative modulation of IL-10 associated microvascular and epithelial repair, which could provide a vital therapeutic strategy to facilitate graft repair in clinical settings.

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Section: Introductionmentioning

confidence: 99%

Targeting Interleukin-10 Restores Graft Microvascular Supply and Airway Epithelium in Rejecting Allografts

Kazmi

Khan

Shamma

et al. 2022

IJMS

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Impact of perioperative airway pathogens on living-donor lobar lung transplantation outcomes

et al. 2023

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Unraveling the spectrum of airway complications following lung transplantation: a comprehensive overview

Dhanani,

Criner,

Criner

2024

Current Opinion in Organ Transplantation

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Purpose of review This review delves into the intricate landscape of airway complications post lung transplantation. With the rising prevalence of end-stage lung disease and the increasing number of lung transplantation worldwide, understanding and effectively managing airway complications are crucial. Given the nuanced nature of these complications and the array of treatment options available, this review aims to provide a comprehensive overview of how to identify, classify, mitigate risk factors for, and manage these complications. Recent findings Several donor, recipient, and surgical risk factors are associated with the increased risk of airway complications. In managing these complications, bronchoscopic interventions, notably balloon dilation and stenting, are pivotal. Although self-expanding metallic stents offer versatility, silicone stents are preferred in certain scenarios for their durability. Emerging techniques such as biodegradable stents and advancing imaging modalities show promise in mitigating complications and improving outcomes. Summary These findings underscore the significance of a multidisciplinary approach and personalized treatment algorithms in managing airway complications post lung transplantation. By elucidating specific indications and complications of treatment modalities, this review serves as a valuable resource for optimally managing airway complications. Ongoing research into novel interventions holds promise for further enhancing outcomes in this challenging clinical setting.

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Airway cilia recovery post lung transplantation

Cited by 5 publications

References 21 publications

Targeting Interleukin-10 Restores Graft Microvascular Supply and Airway Epithelium in Rejecting Allografts

Targeting Interleukin-10 Restores Graft Microvascular Supply and Airway Epithelium in Rejecting Allografts

Impact of perioperative airway pathogens on living-donor lobar lung transplantation outcomes

Unraveling the spectrum of airway complications following lung transplantation: a comprehensive overview

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