Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Sibila, Oriol; Laserna, Elena; Shoemark, Amelia; Keir, Holly R.; Finch, Simon; Rodrigo-Troyano, Ana; Perea, Lídia; Lonergan, Mike; Goeminne, Pieter; Chalmers, James D.

doi:10.1164/rccm.201809-1651oc

Cited by 80 publications

(63 citation statements)

References 23 publications

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“…Exacerbations in bronchiectasis can be caused by a range of bacteria, viruses and environmental factors; making it hard to determine the role of the microbiome in exacerbations [51]. It is known from culture studies that bacterial load is important in lung inflammation and treatment response [14,52]. Microbiome changes during exacerbation are heterogeneous.…”

Section: Does the Microbiome Play A Role In Exacerbations And Affect mentioning

confidence: 99%

The microbiome in bronchiectasis

et al. 2019

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Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the disease and the inflammatory, infective and molecular drivers of disease progression are not fully understood, making the development of novel treatments challenging. Understanding the role bacteria play in disease progression has been enhanced by the use of next-generation sequencing techniques such as 16S rRNA sequencing. The microbiome has not been extensively studied in bronchiectasis, but existing data show lung bacterial communities dominated by Pseudomonas, Haemophilus and Streptococcus, while exhibiting intraindividual stability and large interindividual variability. Pseudomonas- and Haemophilus-dominated microbiomes have been shown to be linked to severe disease and frequent exacerbations. Studies completed to date are limited in size and do not fully represent all clinically observed disease subtypes. Further research is required to understand the microbiomes role in bronchiectasis disease progression. This review discusses recent developments and future perspectives on the lung microbiome in bronchiectasis.

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Section: Does the Microbiome Play A Role In Exacerbations And Affect mentioning

confidence: 99%

The microbiome in bronchiectasis

et al. 2019

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“…The authors studied a large cohort of patients with IPF who underwent both research bronchoscopy and quantitative interpretations of chest computed tomography (CT) scans. To characterise lung bacteria, the authors quantified total lung bacterial DNA burden, which has been the most consistent microbial predictor of clinical outcomes across respiratory conditions [11,13,20,21]. In their analysis of CT imaging, they quantified the severity and extent of fibrosis, including key features such as traction bronchiectasis and honeycombing.…”

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Making the case for causality: what role do lung microbiota play in idiopathic pulmonary fibrosis?

2020

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“…33–41) have undertaken a post hoc analysis of two negative trials in patients with non–cystic fibrosis bronchiectasis (8) and generated important messages for clinicians, scientists, and the pharmaceutical industry. The data confirm a relationship between routine quantitative microbiology with a bacterial load of 10 7 cfu and neutrophilic inflammation as reflected by the green color of myeloperoxidase.…”

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Corporate Memory and Rediscovering the Wheel

Stockley

2019

Am J Respir Crit Care Med

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Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Cited by 80 publications

References 23 publications

The microbiome in bronchiectasis

The microbiome in bronchiectasis

Making the case for causality: what role do lung microbiota play in idiopathic pulmonary fibrosis?

Corporate Memory and Rediscovering the Wheel

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