Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model
Carolyn J. Wang,
Jeremy T. Smith,
David Lu
et al.
Abstract:Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling. Therefore, the aim of the study was to determine the effects of kisspeptin/kisspeptin receptor signalling in the … Show more
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