Abstract:Low-frequency respiratory impedance (Zrs) was measured by applying a forcing signal, between 0.5 and 21 Hz at a transrespiratory pressure of 20 cm H(2)O, in a cross-sectional study of 37 normal infants. A model containing an airway resistance (Raw) and inertance (Iaw) and a tissue damping (G) and elastance (H) was fitted to the individual Zrs. Forced expiratory volume in 0.5 second (FEV(0.5)) was determined using the raised volume rapid thoracic compression technique. Multivariate regression analysis was used … Show more
“…No similar comparative data for R aw exist for the preterm newborn infant at raised lung volume, however, the resistances observed in this study are of similar magnitude to previously published relationships between resistance and length using the LFOT technique in older infants (14). The discrepancy between changes in tissue and airway parameters is indicative of the marked growth occurring in the lung parenchyma during this developmental period.…”
Section: Lung Function In Unsedated Newbornssupporting
confidence: 79%
“…A greater frequency dependence of respiratory resistance (rate of decrease in respiratory resistance with increasing frequency) in these small infants compared with that in older infant populations enabled the use of oscillatory signals of a higher fundamental frequency and consequent shorter durations of the oscillatory measurements than those used previously (13,14). Respiratory reactance remained negative in the measured frequency range, reflecting the dominance of the elastic properties of the respiratory system and the small influence of the inertive properties.…”
Section: Resultsmentioning
confidence: 93%
“…This difficulty has been overcome recently in sedated infants aged from 1 mo to 2 yrs by employing the Hering-Breuer inflation reflex and hyperventilation to induce a short apneic interval (11), during which low-frequency (0.5-20 Hz) Z rs (11)(12)(13)(14)(15)(16)(17) is measured. The use of sedation is generally contraindicated for lung function tests in healthy, spontaneously breathing infants Ͻ44 wk postconceptional age (18).…”
“…No similar comparative data for R aw exist for the preterm newborn infant at raised lung volume, however, the resistances observed in this study are of similar magnitude to previously published relationships between resistance and length using the LFOT technique in older infants (14). The discrepancy between changes in tissue and airway parameters is indicative of the marked growth occurring in the lung parenchyma during this developmental period.…”
Section: Lung Function In Unsedated Newbornssupporting
confidence: 79%
“…A greater frequency dependence of respiratory resistance (rate of decrease in respiratory resistance with increasing frequency) in these small infants compared with that in older infant populations enabled the use of oscillatory signals of a higher fundamental frequency and consequent shorter durations of the oscillatory measurements than those used previously (13,14). Respiratory reactance remained negative in the measured frequency range, reflecting the dominance of the elastic properties of the respiratory system and the small influence of the inertive properties.…”
Section: Resultsmentioning
confidence: 93%
“…This difficulty has been overcome recently in sedated infants aged from 1 mo to 2 yrs by employing the Hering-Breuer inflation reflex and hyperventilation to induce a short apneic interval (11), during which low-frequency (0.5-20 Hz) Z rs (11)(12)(13)(14)(15)(16)(17) is measured. The use of sedation is generally contraindicated for lung function tests in healthy, spontaneously breathing infants Ͻ44 wk postconceptional age (18).…”
“…The post-hyperventilation apnoea permits oscillatory measurements at lower transrespiratory pressures [150]. Further studies with this technique included the establishment of normal values of the mechanical parameters for this age group [151], the evaluation of bronchodilator [152] and bronchoconstrictor provocation tests [153], addressed the alterations in the mechanical properties in wheeze [154] and the contribution of the nasal pathways to Zrs [155].…”
The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory mechanics. FOT employs small-amplitude pressure oscillations superimposed on the normal breathing and therefore has the advantage over conventional lung function techniques that it does not require the performance of respiratory manoeuvres.The present European Respiratory Society Task Force Report describes the basic principle of the technique and gives guidelines for the application and interpretation of FOT as a routine lung function test in the clinical setting, for both adult and paediatric populations.FOT data, especially those measured at the lower frequencies, are sensitive to airway obstruction, but do not discriminate between obstructive and restrictive lung disorders. There is no consensus regarding the sensitivity of FOT for bronchodilation testing in adults. Values of respiratory resistance have proved sensitive to bronchodilation in children, although the reported cutoff levels remain to be confirmed in future studies.Forced oscillation technique is a reliable method in the assessment of bronchial hyperresponsiveness in adults and children. Moreover, in contrast with spirometry where a deep inspiration is needed, forced oscillation technique does not modify the airway smooth muscle tone. Forced oscillation technique has been shown to be as sensitive as spirometry in detecting impairments of lung function due to smoking or exposure to occupational hazards. Together with the minimal requirement for the subject9s cooperation, this makes forced oscillation technique an ideal lung function test for epidemiological and field studies. Novel applications of forced oscillation technique in the clinical setting include the monitoring of respiratory mechanics during mechanical ventilation and sleep.
“…Results are reported as z-scores (FEVZ) using normative data calculated from healthy children tested at Princess Margaret Hospital, Perth, Australia [16]. Exhaled NO FeNO was measured with a chemiluminescence analyser (NOA 280; Seivers Instruments Inc., Boulder, CO, USA) using the single-breath technique as described previously [14].…”
Fractional exhaled nitric oxide (FeNO) has been reported to be reduced in cystic fibrosis (CF) patients. However, data from young children are conflicting and it is not clear whether this is a primary feature of the disease or a secondary response. The present study compared FeNO between CF and healthy infants using a validated single-breath technique.A total of 23 healthy infants (11 females; mean age 40.1 weeks) and 18 infants with CF (nine females; 64.9 weeks) underwent tests of lung function and FeNO. Bronchoalveolar lavage (BAL) was collected from all CF infants 2-5 days after lung function testing.There was no significant difference in FeNO between the CF and healthy infants (geometric mean: 23.1 parts per billion (ppb) and 17.0 ppb, respectively). There was an inverse relationship between age and FeNO in the CF patients, but not in the healthy group. Within the CF group, there was no association between FeNO and any marker of airway inflammation measured in the BAL.Exhaled nitric oxide is not reduced in cystic fibrosis infants, but does decrease with age. The current data indicate that FeNO is not a good marker of airway inflammation in cystic fibrosis.
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