Airway and parenchymal manifestations of pulmonary aspergillosis

Abstract

Pulmonary aspergillosis encompasses a heterogeneous group of mycoses that result from either colonisation or pathogenic damage of lung tissue by Aspergillus fungi. These clinical entities range from relatively benign saprophytic hypersensitivity associated with fungal inhabitation to life threatening invasive disease. The diagnosis of pulmonary disorders related to Aspergillus is on the increase and it is more important than ever those both general and respiratory physicians have a good understanding of these disorders. This paper reviews the contemporary understanding of the clinical, radiographic and histopathological aspects of pulmonary aspergillosis.

The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis

“…[5][6][7] ABPA affects between 2%-15% of patients with CF (PWCF) and recurrent episodes impact pulmonary function. 1, [8][9][10][11] It manifests as an allergic, hypersensitive, Th2 CD4 + cell-driven response to Af and the diagnosis of ABPA in CF is particularly challenging due to overlapping clinical, immunological and radiological features that are similar to those of a pulmonary exacerbation. To address this, consensus conference criteria were published to aid clinicians in diagnosing CF-ABPA.…”

Airway centered invasive pulmonary aspergillosis in an immunocompetent patient: case report and literature review

“…The diagnosis of proven IPA usually is based on histopathological confirmation with tissue invasion, including septated, acutely branching filamentous fungi, and a positive culture result for a specimen from a normally sterile site (1,2). It usually occurs in immunocompromised patients, especially in patients with neutropenia (2)(3)(4). Invasive pulmonary aspergillosis has been categorized into an angioinvasive and an airway centered invasive form depending on where Aspergillus mainly invades (2,4,5).…”

Pulmonary solid tumor with coexisting pulmonary aspergillosis: case reports and literature review

“…Pulmonary aspergillosis includes a heterogeneous group of mycoses that result from either colonization or pathogenic damage of lung tissue by Aspergillus fungi (1). Aspergillosis is primarily seen in immunocompromised patients or those with underlying chronic lung diseases.…”