Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests

Petersson-Sjögren, Madeleine; Jakobsson, Jonas; Aaltonen, H Laura; Nicklasson, Hanna; Rissler, Jenny; Engström, Gunnar; Wollmer, Per; Löndahl, Jakob

doi:10.2147/ijn.s360271

Cited by 3 publications

(6 citation statements)

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“…Similarly, to the previously mentioned study SCAPIS using AiDA on a larger Swedish population (n=695) aged 50-65 years, we found significant correlation between r AiDA and percent predicted FVC and FEV1 in dynamic spirometry as well as several IOS indices [27].…”

Section: Discussionsupporting

confidence: 87%

“…Similarly to the previously mentioned study SCAPIS using AiDA on a larger Swedish population (n=695) aged 50–65 years, we found significant correlation between r AiDA and forced vital capacity (FVC) % predicted and FEV 1 in dynamic spirometry as well as several IOS indices [ 27 ]. In other studies, AiDA parameters were found to be correlated with results of 129 Xe DW-MRI [ 16 ] and CT of the lungs [ 15 ].…”

Section: Discussionsupporting

confidence: 74%

“…R 0 is suspected to be correlated with particle loss during the dynamic process of breathing and represents heterogeneity in the acini (the distal airways). However, interpretation requires further studies [ 16 , 19 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we opted for a simple measurement of years active as a firefighter and hoped that this would give us an adequate assessment at a group level. In a previous study, r AiDA was found to be correlated to smoking measured as pack-years [ 27 ]. A more detailed investigation of the link between the extent and type of occupational exposure in firefighters and AiDA measurements should be considered in future studies.…”

Section: Discussionmentioning

confidence: 99%

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Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters

et al. 2023

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IntroductionFirefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in chronic obstructive pulmonary disease. This method may be useful in the occupational setting to detect early pulmonary changes and enable prevention.AimTo evaluate whether AiDA detects changes in the most peripheral airways of firefighters.MethodsAiDA, measuring the effective airspace radius (rAiDA) and zero-second recovery (R0), was used as a complement to other standardised lung function measures in 21 male firefighters and 16 age-matched male controls.ResultsThere were significant differences inrAiDAandR0between firefighters (meanrAiDA0.301 mm, standard deviation (sd) 0.024; meanR00.336 arbitrary units,sd0.116 and controls (meanrAiDA0.276 mm,sd0.044; meanR00.576 arbitrary units,sd0.168), p=0.03 and p<0.001, respectively. Higher forced vital capacity was found in firefighters (mean 101% of predicted) than in controls (mean 93% of predicted; p=0.03). No significant differences were found with regard to either the ratio between forced expiratory volume in 1 s and forced vital capacity or forced expiratory volume in 1 s. The majority of firefighters had diffusing capacity for carbon monoxide, oscillometry and single-breath nitrogen washout values within the normal ranges.ConclusionAiDA parameters can provide information on early pulmonary peripheral changes that may not be seen with standard techniques used in screening of pulmonary function.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters

et al. 2023

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“…The observed decrease in R 0 can be explained by less deposition in the conducting airways at a shorter and shallower breathing cycle. However, R 0 measured at full in ation has earlier been shown to correlate with measures of lung heterogeneity [35,37]. The decreased R 0 at the smaller inhaled volume with particles could also be due to a larger in uence of entrainment and mixing with particle free air from the residual volume (the relative volume of air with particles is smaller at half in ation compared to the particle free air in the residual volume), which would strengthen the hypothesis that R 0 is a measure of lung heterogeneity.…”

Section: Aida At Half In Ationmentioning

confidence: 99%

An experimental study on lung deposition of inhaled 2 µm particles in relation to lung characteristics and deposition models

Rissler

Sjögren

Linell

et al. 2023

Preprint

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Background. The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles and the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles >1 µm. Methods. We designed an experimental set-up to measure deposition in the respiratory tract for particles >1 µm, more specifically 2 µm, with careful consideration to minimise forseen errors. We measured the deposition in seventeen healthy adults (21–68 years). The measurements were performed at tidal breathing, during three consecutive 5-minute periods while logging breathing patterns. Pulmonary function tests were performed, including the new airspace dimension assessment (AiDA) method measuring distal lung airspace radius (rAiDA). The lung characteristics and breathing variables were used in statistical models to investigate to what extent they can explain individual variations in measured deposited particle fraction. The measured particle deposition was compared to values predicted with whole lung models. Model calculations were made for each subject using measured variables as input (e.g., breathing pattern and functional residual capacity). Results. The measured fractional deposition for 2 µm particles was 0.60 0.14, which is significantly higher than predicted by any of the models tested, ranging from 0.37 0.08 to 0.53 0.09. The multiple-path particle dosimetry (MPPD) model most closely predicted the measured deposition when using the new PNNL lung model. The main individual variability in measured particle deposition was best explained by breathing pattern and distal airspace radius (rAiDA) at half inflation from AiDA. All models underestimated inter-subject variability even though the individual breathing pattern and functional residual capacity for each participant was used in the model. Conclusions. Whole lung models need to be tuned and improved to predict the respiratory tract particle deposition of micron-sized particles, and to capture individual variations – a variation that is known to be higher for diseased lungs. Further, the results support the hypothesis that the AiDA method measures dimensions in the peripheral lung and that rAiDA, as measured by the AiDA, can be used to better understand the individual variation in the dose to healthy and diseased lungs.

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An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models

Rissler,

Sjögren,

Linell

et al. 2023

Part Fibre Toxicol

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Background The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm. Methods We designed an experimental set-up to measure deposition in the respiratory tract for particles > 1 μm, more specifically 2.3 μm, with careful consideration to minimise foreseen errors. We measured the deposition in seventeen healthy adults (21–68 years). The measurements were performed at tidal breathing, during three consecutive 5-minute periods while logging breathing patterns. Pulmonary function tests were performed, including the new airspace dimension assessment (AiDA) method measuring distal lung airspace radius (rAiDA). The lung characteristics and breathing variables were used in statistical models to investigate to what extent they can explain individual variations in measured deposited particle fraction. The measured particle deposition was compared to values predicted with whole lung models. Model calculations were made for each subject using measured variables as input (e.g., breathing pattern and functional residual capacity). Results The measured fractional deposition for 2.3 μm particles was 0.60 ± 0.14, which is significantly higher than predicted by any of the models tested, ranging from 0.37 ± 0.08 to 0.53 ± 0.09. The multiple-path particle dosimetry (MPPD) model most closely predicted the measured deposition when using the new PNNL lung model. The individual variability in measured particle deposition was best explained by breathing pattern and distal airspace radius (rAiDA) at half inflation from AiDA. All models underestimated inter-subject variability even though the individual breathing pattern and functional residual capacity for each participant was used in the model. Conclusions Whole lung models need to be tuned and improved to predict the respiratory tract particle deposition of micron-sized particles, and to capture individual variations – a variation that is known to be higher for aged and diseased lungs. Further, the results support the hypothesis that the AiDA method measures dimensions in the peripheral lung and that rAiDA, as measured by the AiDA, can be used to better understand the individual variation in the dose to healthy and diseased lungs.

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Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests

Cited by 3 publications

References 48 publications

Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters

Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters

An experimental study on lung deposition of inhaled 2 µm particles in relation to lung characteristics and deposition models

An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models

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