Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization

Gualtieri, Maurizio; Øvrevik, Johan; Mollerup, Steen; Asare, Nana; Longhin, Eleonora; Dahlman, Hans-Jørgen; Camatini, Marina; Holme, Jørn A.

doi:10.1016/j.mrfmmm.2011.05.011

Cited by 150 publications

(92 citation statements)

References 80 publications

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“…As a major receptor for polycyclic aromatic hydrocarbons (PAHs), AHR and its downstream targets play an important role in mediating cell adaptation and detoxification in response to environmental PAHs. PM induced AHR activation and subsequent induction of detoxification enzymes have been reported in A549, BEAS-2B and other cell types (Courter et al 2008; Dieme et al 2012; Gualtieri et al 2011; Gualtieri et al 2012; Mahadevan et al 2005). …”

Section: Discussionmentioning

confidence: 77%

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

Sun

Shamy

Kluz

et al. 2012

Toxicology and Applied Pharmacology

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Epidemiological studies have established a positive correlation between human mortality and increased concentration of airborne particulate matters (PM). However, the mechanisms underlying PM related human diseases, as well as the molecules and pathways mediating the cellular response to PM, are not fully understood. This study aims to investigate the global gene expression changes in human cells exposed to PM10 and to identify genes and pathways that may contribute to PM related adverse health effects. Human bronchial epithelial cells were exposed to PM10 collected from Saudi Arabia for 1 or 4 days, and whole transcript expression was profiled using the GeneChip human gene 1.0 ST array. A total of 140 and 230 genes were identified that significantly changed more than 1.5 fold after PM10 exposure for 1 or 4 days, respectively. Ingenuity Pathway Analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1 day exposure. In contrast, cells exposed for 4 days exhibited significant changes in genes related to cholesterol and lipid synthesis pathways. These observed changes in cellular oxidative stress and lipid synthesis might contribute to PM related respiratory and cardiovascular disease.

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Section: Discussionmentioning

confidence: 77%

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

Sun

Shamy

Kluz

et al. 2012

Toxicology and Applied Pharmacology

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“…Longhin et al (2013) reported the correlation of OC and DNA damage in an urban environment. OC correlated with oxidative potential in the Long Beach harbour area and in traffic-exhaust-dominated areas (Gualtieri et al, 2011;Verma et al, 2011). The limited body of evidence concerning ambient aged particles shows that SOA correlates with oxidative potential Rattanavaraha et al, 2011;McWhinney et al, 2013) and with cytotoxicity (Jalava et al, 2009).…”

Section: Particulate Matter and Healthmentioning

confidence: 99%

Particulate matter, air quality and climate: lessons learned and future needs

et al. 2015

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Abstract. The literature on atmospheric particulate matter (PM), or atmospheric aerosol, has increased enormously over the last 2 decades and amounts now to some 1500-2000 papers per year in the refereed literature. This is in part due to the enormous advances in measurement technologies, which have allowed for an increasingly accurate understanding of the chemical composition and of the physical properties of atmospheric particles and of their processes in the atmosphere. The growing scientific interest in atmospheric aerosol particles is due to their high importance for environmental policy. In fact, particulate matter constitutes one of the most challenging problems both for air quality and for climate change policies. In this context, this paper reviews the most recent results within the atmospheric aerosol sciences and the policy needs, which have driven much of the increase in monitoring and mechanistic research over the last 2 decades.The synthesis reveals many new processes and developments in the science underpinning climate-aerosol interactions and effects of PM on human health and the environment. However, while airborne particulate matter is responsible for globally important influences on premature human mortality, we still do not know the relative importance of the different chemical components of PM for these effects. Likewise, the magnitude of the overall effects of PM on climate remains highly uncertain. Despite the uncertainty there are many things that could be done to mitigate local and global problems of atmospheric PM. Recent analyses have shown that reducing black carbon (BC) emissions, using known control measures, would reduce global warming and delay the time when anthropogenic effects on global temperature would exceed 2 • C. Likewise, cost-effective control measures on ammonia, an important agricultural precursor gas for secondary inorganic aerosols (SIA), would reduce regional eutrophication and PM concentrations in large areas of Europe, China and the USA. Thus, there is much that could be done to reduce the effects of atmospheric PM on the climate and the health of the environment and the human population.A prioritized list of actions to mitigate the full range of effects of PM is currently undeliverable due to shortcomings in the knowledge of aerosol science; among the shortcomings, the roles of PM in global climate and the relative roles of Published by Copernicus Publications on behalf of the European Geosciences Union. 8218S. Fuzzi et al.: Particulate matter, air quality and climate different PM precursor sources and their response to climate and land use change over the remaining decades of this century are prominent. In any case, the evidence from this paper strongly advocates for an integrated approach to air quality and climate policies.

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“…Recorded levels of PM with grain size ≤10 µm (PM 10 ) are often above 100 µg m −3 especially during winter months, with a daily yearly average of 50 µg m −3 (Marcazzan et al 2001;Ozgen et al 2016). It is well known that airborne PM is linked with respiratory illness (Donaldson 2003;Faustini et al 2011;Gualtieri et al 2011;Bigi & Ghermandi 2014;Chiesa et al 2014;Kim et al 2015). Transition metal components such as iron are particularly harmful as they have the potential to produce reactive oxygen species causing inflammation throughout the body (Zhou et al 2003;Birben et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Investigating distribution patterns of airborne magnetic grains trapped in tree barks in Milan, Italy: insights for pollution mitigation strategies

Vezzola¹,

Muttoni

Merlini³

et al. 2017

Geophysical Journal International

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Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization

Cited by 150 publications

References 80 publications

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

Particulate matter, air quality and climate: lessons learned and future needs

Investigating distribution patterns of airborne magnetic grains trapped in tree barks in Milan, Italy: insights for pollution mitigation strategies

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