Airborne SARS-CoV-2

Dancer, Stephanie J.

doi:10.1136/bmj.o1408

Cited by 3 publications

(3 citation statements)

References 33 publications

(45 reference statements)

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“…And it could be the most severe threat for generations due to its dangerousness and unpredictability [ 1 ]. Great efforts have been made to understand and discover SARS-CoV-2, including its viral structure [ 2 , 3 , 4 ], spread process [ 5 , 6 , 7 , 8 ], pathogenesis mechanism [ 9 , 10 ], diagnostic approach [ 8 ], variants [ 11 , 12 , 13 ], and vaccine immunity [ 13 , 14 , 15 ]. However, there are still significant challenges in the detection of this virus despite all kinds of positive scientific progress have been achieved.…”

Section: Introductionmentioning

confidence: 99%

Identify the Virus-like Models for COVID-19 as Bio-Threats: Combining Phage Display, Spectral Detection and Algorithms Analysis

Wu¹,

Liu²,

Mao

et al. 2023

IJMS

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The rapid identification and recognition of COVID-19 have been challenging since its outbreak. Multiple methods were developed to realize fast monitoring early to prevent and control the pandemic. In addition, it is difficult and unrealistic to apply the actual virus to study and research because of the highly infectious and pathogenic SARS-CoV-2. In this study, the virus-like models were designed and produced to replace the original virus as bio-threats. Three-dimensional excitation-emission matrix fluorescence and Raman spectroscopy were employed for differentiation and recognition among the produced bio-threats and other viruses, proteins, and bacteria. Combined with PCA and LDA analysis, the identification of the models for SARS-CoV-2 was achieved, reaching a correction of 88.9% and 96.3% after cross-validation, respectively. This idea might provide a possible pattern for detecting and controlling SARS-CoV-2 from the perspective of combining optics and algorithms, which could be applied in the early-warning system against COVID-19 or other bio-threats in the future.

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Section: Introductionmentioning

confidence: 99%

Identify the Virus-like Models for COVID-19 as Bio-Threats: Combining Phage Display, Spectral Detection and Algorithms Analysis

Wu¹,

Liu²,

Mao

et al. 2023

IJMS

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“… Abstract Aerosol inhalation is increasingly well recognized as a major if not primary mode of transmission of SARS-CoV-2 1,2 . Over the course of the COVID-19 pandemic, three highly transmissible lineages evolved and became globally dominant 3 .…”

mentioning

confidence: 99%

Evolution of SARS-CoV-2 Shedding in Exhaled Breath Aerosols

Lai

Coleman

Tai

et al. 2022

Preprint

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Aerosol inhalation is increasingly well recognized as a major if not primary mode of transmission of SARS-CoV-2. Over the course of the COVID-19 pandemic, three highly transmissible lineages evolved and became globally dominant. One hypothesis to explain increased transmissibility is that natural selection favours variants with higher rates of viral aerosol shedding. However, the extent of aerosol shedding of successive SARS-CoV-2 variants is unknown. Here, we demonstrate that viral shedding (measured as RNA copies) into exhaled breath aerosol was significantly greater during infections with Alpha, Delta, and Omicron than with ancestral strains and variants not associated with increased transmissibility. The three highly transmissible variants independently evolved a high viral aerosol shedding phenotype, demonstrating convergent evolution. We did not observe statistically significant differences in rates of shedding between Alpha, Delta, and Omicron infections. The highest shedder in our study, however, had an Omicron infection and shed three orders of magnitude more viral RNA copies than the maximum observed for Delta and Alpha. Our results also show that fully vaccinated and boosted individuals, when infected, can shed infectious SARS-CoV-2 via exhaled breath aerosols. These findings provide additional evidence that inhalation of infectious aerosols is the dominant mode of transmission and emphasize the importance of ventilation, filtration, and air disinfection to mitigate the pandemic and protect vulnerable populations. We anticipate that monitoring aerosol shedding from new SARS-CoV-2 variants and emerging pathogens will be an important component of future threat assessments and will help guide interventions to prevent transmission via inhalation exposure.

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“…89 Other priorities are at play when major national drug regulators and “independent advisers” are funded extensively by the industry and make decisions that unduly favour it, as our new investigation shows (doi:10.1136/bmj.o1538). 10 Which priorities drive the reluctance to accept the evidence on airborne transmission of SARS-CoV-2, to which we add a new review (doi:10.1136/bmj-2021-068743, 10.1136/bmj.o1408)?1112 Are they related to the commercial and legal missteps in protecting healthcare professionals?…”

mentioning

confidence: 99%